Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer.
Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer.
复制标题
DOI：
10.1186/1479-5876-7-38
复制
发表时间：
2009-05-28
影响因子：
7.4
通讯作者：
Lim JB
中科院分区：
文献类型：
--
作者：
Chung HW;Lee SG;Kim H;Hong DJ;Chung JB;Stroncek D;Lim JB
高迁移率族蛋白-1(HMGB1)是新近发现的一种调节肿瘤细胞发生、增殖和侵袭的因子。探讨血清HMGB1水平与胃癌临床病理特征的相关性，评价HMGB1作为胃癌早期诊断标志物的有效性。按胃炎-异型增生-癌发生顺序将227例受试者分为5组，用酶联免疫吸附分析法检测血清HMGB1水平。以临床参数、国际抗癌联合会(UICC)的TNM分期、肿瘤大小、分化程度或淋巴侵犯、血管或神经周围侵犯及预后作为分析变量。血清HMGB1水平在不同疾病组间差异有统计学意义(ANOVA，p<；0.05)，且HMGB1水平随胃癌发生发展有升高趋势。血清HMGB1水平与肿瘤侵袭深度、淋巴结转移、肿瘤大小和预后不良显著相关(p<；0.05)。然而，HMGB1水平与患者性别、年龄、肿瘤细胞分化、淋巴、血管和神经周围侵犯以及晚期癌症是否存在远处转移无关(p>；0.05)。血清HMGB1诊断早期胃癌的敏感度和特异度分别为71%和67%(以5 ng/ml为界值)，诊断高危病变的敏感度和特异度分别为70%和%(以4 ng/ml为界值)。这些值大于癌胚抗原(CEA)的值(敏感度30-40%)。HMGB1是一种有用的血清生物标志物，可用于胃癌的早期诊断以及评估肿瘤的发生、分期和预后。
High mobility group box-1 (HMGB1) is a newly recognized factor regulating cancer cell tumorigenesis, expansion and invasion. We investigated the correlation between the serum HMGB1 levels and the clinical and pathologic features of gastric cancer and evaluated the validity of HMGB1 as a potential biomarker for the early diagnosis of gastric cancer. A total of 227 subjects were classified into 5 disease groups according to the 'gastritis-dysplasia-carcinoma' sequence of gastric carcinogenesis and their serum levels of HMGB1 were analyzed by an enzyme-linked immunosorbent assay (ELISA) method. Clinical parameters, International Union Against Cancer (UICC) TNM stage, cancer size, differentiation or lymphatic invasion, vascular or perineural invasion and prognosis were used as analysis variables. The serum HMGB1 levels were significantly different among disease groups (ANOVA, p < 0.05) and HMGB1 levels tended to increase according to the progression of gastric carcinogenesis. Serum HMGB1 levels were significantly associated with depth of invasion, lymph node metastasis, tumor size, and poor prognosis (p < 0.05). However, HMGB1 levels were not associated with patient gender or age, differentiation of tumor cells, or lymphatic, vascular and perineural invasion, or the existence of distant metastasis in advanced cancer (p > 0.05). The sensitivity and specificity of serum HMGB1 was 71% and 67% (cut-off value of 5 ng/ml) for the diagnosis of early gastric cancer, and 70% and 64% (cut-off value of 4 ng/ml) for the diagnosis of high-risk lesions, respectively. These values were greater than those for carcinoembryonic antigen (CEA) (30–40% of sensitivity). HMGB1 appears to be a useful serological biomarker for early diagnosis as well as evaluating the tumorigenesis, stage, and prognosis of gastric cancer.
登录
查看更多内容
影响因子：
64.8
作者：
Scaffidi, P;Misteli, T;Bianchi, ME
通讯作者：
Bianchi, ME
影响因子：
2.9
作者：
Chung, Hye Won;Kim, Ju Won;Lim, Jong-Baeck
通讯作者：
Lim, Jong-Baeck
影响因子：
3.9
作者：
NAKOPOULOU, L;ZINOZI, M;PAPACHARALAMPOUS, N
通讯作者：
PAPACHARALAMPOUS, N
影响因子：
64.8
作者：
REVESZ, L
通讯作者：
REVESZ, L
影响因子：
6
作者：
Kuniyasu, H;Yano, S;Ohmori, H
通讯作者：
Ohmori, H