Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling.
Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling.
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DOI：
10.3892/ol.2013.1591
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发表时间：
2013-12
期刊：
影响因子：
2.9
通讯作者：
Komohara Y
中科院分区：
文献类型：
--
作者：
Fujiwara Y;Takaishi K;Nakao J;Ikeda T;Katabuchi H;Takeya M;Komohara Y
化疗耐药是晚期上皮性卵巢癌患者治疗的一个严重问题。化疗耐药的机制是复杂的，研究表明信号换能器和转录激活因子3 （STAT3）信号在癌细胞的化疗耐药中起作用。本研究调查了之前被报道为STAT3抑制剂的corosolic acid （CA）是否能够增加上皮性卵巢癌细胞对化疗药物的敏感性。CA还能显著增强紫杉醇、顺铂和阿霉素的抗癌作用。此外，CA消除了巨噬细胞与上皮性卵巢癌细胞之间的细胞间相互作用，抑制了巨噬细胞诱导的上皮性卵巢癌细胞活化。这些数据表明，CA能够逆转上皮性卵巢癌细胞的化疗耐药，并抑制与致瘤性巨噬细胞的细胞间相互作用。因此，由于CA的多重抗癌作用，它可以作为晚期卵巢癌和其他类型癌症患者的辅助治疗。
Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells. The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell-cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage-induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell-cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects.
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影响因子：
1.5
作者：
Komohara, Yoshihiro;Horlad, Hasita;Takeya, Motohiro
通讯作者：
Takeya, Motohiro
影响因子：
2.2
作者：
Kawamura, Kyoko;Komohara, Yoshihiro;Takeya, Motohiro
通讯作者：
Takeya, Motohiro
影响因子：
5.7
作者：
Takaishi, Kiyomi;Komohara, Yoshihiro;Takeya, Motohiro
通讯作者：
Takeya, Motohiro
STAT3诱饵寡脱氧核苷酸对人上皮性卵巢癌细胞的细胞侵袭和化疗敏感性的作用。
影响因子：
--
作者：
Zhang, Xiaolei;Liu, Peishu;Yang, Meixiang
通讯作者：
Yang, Meixiang
DOI：
10.1097/igc.0b013e31826bd1f2
发表时间：
2012-10
期刊：
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
影响因子：
--
作者：
Modugno F;Edwards RP
通讯作者：
Edwards RP