Spectral diffusion analysis of kidney intravoxel incoherent motion MRI in healthy volunteers and patients with renal pathologies
Spectral diffusion analysis of kidney intravoxel incoherent motion MRI in healthy volunteers and patients with renal pathologies
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健康志愿者和肾病患者肾脏体素不相干运动 MRI 的光谱扩散分析
DOI：
10.1002/mrm.28631
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发表时间：
--
影响因子：
3.3
通讯作者：
Wittsack H-J
中科院分区：
文献类型：
--
作者：
Stabinska J;Ljimani A;Zöllner HJ;Wilken E;Benkert T;Limberg J;Esposito I;Antoch G;Wittsack H-J
PurposeTo评估测量肾小管和血管信号分数在人类肾脏使用非负最小二乘（NNLS）分析intravoxel非相干运动数据收集在健康志愿者和患者的肾脏pathology.MethodsMR成像的可行性进行了3特斯拉在12名健康受试者和3名患者的各种肾脏病变（纤维化肾病，肾移植失败，肾肿块）。采用正则化NNLS拟合体素内非相干运动数据，获得皮质、髓质和肾脏病变中弥散成分的相对信号分数f和平均弥散系数。在5名志愿者扫描twice.ResultsIn健康的肾脏，NNLS方法产生的扩散光谱与3个可区分的组件，可能与缓慢的组织水扩散，中间管和血管流，和快速血流在较大的血管中的相对信号分数，fslow，fintermandffast，分别测试的NNLS方法的重测重复性。在病理肾脏中，扩散光谱与在健康肾脏中获得的扩散光谱有很大不同。总体而言，肾囊肿表现出显着higherfintermand lowerfslow，而纤维化肾，肾移植失败，肾细胞癌表现出相反的trade.ConclusionNNLS为基础的intravoxel不相干运动可能成为一个有价值的工具，在评估病理生理条件下的肾小管和血管容积分数的变化。
PurposeTo assess the feasibility of measuring tubular and vascular signal fractions in the human kidney using nonnegative least‐square (NNLS) analysis of intravoxel incoherent motion data collected in healthy volunteers and patients with renal pathologies.MethodsMR imaging was performed at 3 Tesla in 12 healthy subjects and 3 patients with various kidney pathologies (fibrotic kidney disease, failed renal graft, and renal masses). Relative signal fractionsfand mean diffusivities of the diffusion components in the cortex, medulla, and renal lesions were obtained using the regularized NNLS fitting of the intravoxel incoherent motion data. Test–retest repeatability of the NNLS approach was tested in 5 volunteers scanned twice.ResultsIn the healthy kidneys, the NNLS method yielded diffusion spectra with 3 distinguishable components that may be linked to the slow tissue water diffusion, intermediate tubular and vascular flow, and fast blood flow in larger vessels with the relative signal fractions,fslow,fintermandffast, respectively. In the pathological kidneys, the diffusion spectra varied substantially from those acquired in the healthy kidneys. Overall, the renal cyst showed substantially higherfintermand lowerfslow, whereas the fibrotic kidney, failed renal graft, and renal cell carcinoma demonstrated the opposite trend.ConclusionNNLS‐based intravoxel incoherent motion could potentially become a valuable tool in assessing changes in tubular and vascular volume fractions under pathophysiological conditions.
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影响因子：
2.9
作者：
Chevallier, Olivier;Zhou, Nan;Wang, Yi Xiang J.
通讯作者：
Wang, Yi Xiang J.
影响因子：
3.3
作者：
Wang F;Takahashi K;Li H;Zu Z;Li K;Xu J;Harris RC;Takahashi T;Gore JC
通讯作者：
Gore JC
影响因子：
4.4
作者：
Finsterbusch, Juergen
通讯作者：
Finsterbusch, Juergen
影响因子：
2.2
作者：
WHITTALL, KP;MACKAY, AL
通讯作者：
MACKAY, AL
是否有证据表明腹部器官中存在两种以上的扩散成分——针对健康志愿者的磁共振成像研究？
影响因子：
2.9
作者：
M. Wurnig;Manon Germann;A. Boss
通讯作者：
A. Boss