Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb.
Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb.
复制标题
DOI：
10.1007/s00429-014-0888-4
复制
发表时间：
2016-01
影响因子：
3.1
通讯作者：
Arenkiel BR
中科院分区：
文献类型：
--
作者：
Garcia I;Bhullar PK;Tepe B;Ortiz-Guzman J;Huang L;Herman AM;Chaboub L;Deneen B;Justice NJ;Arenkiel BR
Please try later.
Neuropeptides play important physiological functions during distinct behaviors such as arousal, learning, memory, and reproduction. However, the role of local, extrahypothalamic neuropeptide signaling in shaping synapse formation and neuronal plasticity in the brain is not well understood. Here, we characterize the spatiotemporal expression profile of the neuropeptide CRH and its receptor CRHR1 in in the mouse OB throughout development. We found that CRH-expressing interneurons are enriched in the external plexiform layer, that its cognate receptor is expressed by granule cells, and show that both CRH and CRHR1 expression enriches in the postnatal period when olfaction becomes important towards olfactory related behaviors. Further, we provide electrophysiological evidence that CRHR1-expressing granule cells functionally respond to CRH ligand, and that the physiological circuitry of CRHR1 knockout mice is abnormal, leading to impaired olfactory behaviors. Together, these data suggest a physiologically relevant role for local CRH signaling towards shaping the neuronal circuitry within the mouse OB.
登录
查看更多内容
影响因子：
5.2
作者：
Inutsuka A;Yamanaka A
通讯作者：
Yamanaka A
影响因子：
2.9
作者：
Holzer, Peter;Reichmann, Florian;Farzi, Aitak
通讯作者：
Farzi, Aitak
影响因子：
16.2
作者：
Abraham NM;Egger V;Shimshek DR;Renden R;Fukunaga I;Sprengel R;Seeburg PH;Klugmann M;Margrie TW;Schaefer AT;Kuner T
通讯作者：
Kuner T
影响因子：
3.3
作者：
Hamilton, KA;Heinbockel, T;Hayar, A
通讯作者：
Hayar, A
DOI：
10.1523/jneurosci.2490-08.2008
发表时间：
2008-08-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Eyre MD;Antal M;Nusser Z
通讯作者：
Nusser Z