Independent delta/theta rhythms in the human hippocampus and entorhinal cortex.
Independent delta/theta rhythms in the human hippocampus and entorhinal cortex.
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人类海马和内嗅皮质中的独立三角/theta节律。
DOI：
10.3389/neuro.09.003.2008
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发表时间：
2008
影响因子：
2.9
通讯作者：
Lehnertz K
中科院分区：
文献类型：
--
作者：
Mormann F;Osterhage H;Andrzejak RG;Weber B;Fernández G;Fell J;Elger CE;Lehnertz K
哺乳动物内侧颞叶（MTL）的θ波振荡与空间导航、感觉运动整合和认知加工等多种功能有关。虽然θ波节律最初被认为起源于内侧隔，但最近的研究表明，颞下颌颞叶自主产生θ波。虽然已经发现内嗅和海马theta活动之间的一致性影响记忆的形成，但尚不清楚这两个结构是否可以独立产生theta。在这项研究中，我们分析了22例单侧海马硬化症患者的颅内脑电图（EEG）记录，这些患者在切除癫痫病灶前进行了术前评估。使用基于小波的、频率波段特定的相位同步测量，我们量化了非癫痫大脑半球沿海马结构纵轴的10个不同记录位点之间的同步。我们比较了相邻记录位点(i)内嗅皮层、（ii）海马体和（iii）海马体和内嗅皮层之间的EEG同步。我们观察到delta和theta波段的同步性在区域间存在显著差异，表明人类MTL的不同亚区存在独立的delta/theta节律。这些节律的相互作用可能代表了记忆编码和检索所需的信息处理的时间基础。
Theta oscillations in the medial temporal lobe (MTL) of mammals are involved in various functions such as spatial navigation, sensorimotor integration, and cognitive processing. While the theta rhythm was originally assumed to originate in the medial septum, more recent studies suggest autonomous theta generation in the MTL. Although coherence between entorhinal and hippocampal theta activity has been found to influence memory formation, it remains unclear whether these two structures can generate theta independently. In this study we analyzed intracranial electroencephalographic (EEG) recordings from 22 patients with unilateral hippocampal sclerosis undergoing presurgical evaluation prior to resection of the epileptic focus. Using a wavelet-based, frequency-band-specific measure of phase synchronization, we quantified synchrony between 10 different recording sites along the longitudinal axis of the hippocampal formation in the non-epileptic brain hemisphere. We compared EEG synchrony between adjacent recording sites (i) within the entorhinal cortex, (ii) within the hippocampus, and (iii) between the hippocampus and entorhinal cortex. We observed a significant interregional gap in synchrony for the delta and theta band, indicating the existence of independent delta/theta rhythms in different subregions of the human MTL. The interaction of these rhythms could represent the temporal basis for the information processing required for mnemonic encoding and retrieval.
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影响因子：
2.9
作者：
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通讯作者：
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