Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer.
Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer.
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DOI：
10.3892/ol.2013.1326
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发表时间：
2013-07
期刊：
影响因子：
2.9
通讯作者：
Hu L
中科院分区：
文献类型：
--
作者：
Chen J;Wu W;Zhen C;Zhou H;Yang R;Chen L;Hu L
胰腺癌（PC）仍然是一种毁灭性的疾病，5年生存率<5%。早期诊断的困难和转移的频繁发生是导致预后不良的重要原因。在中国，PC的发病率一直在稳步上升。因此，本研究旨在确定早期和晚期PC的有效标志物。采用免疫组织化学、RT-PCR和western blotting检测补体C3、补体C4b1和载脂蛋白E （ApoE）在PC各阶段的表达水平。并对结果进行统计学意义分析。与正常胰腺组织相比，补体C3、补体C4b1和apoE在PC中的表达水平较高。补体C3与肿瘤TNM分期或淋巴结转移无相关性。然而，补体C4b1和apoE与肿瘤TNM分期和淋巴结转移显著相关。补体C3可作为早期PC的诊断标志物，而补体C4b1和apoE与肿瘤发展密切相关，反映了PC的生物学行为，因此可作为晚期PC的诊断标志物。
Pancreatic cancer (PC) remains a devastating disease with a five-year survival rate of <5%. The difficulty in making an early diagnosis and the frequent occurrence of metastasis are important reasons for this poor prognosis. In China, the incidence of PC has been increasing steadily. Therefore, the present study aimed to identify effective markers in the early and advanced stages of PC. The expression levels of complement C3, complement C4b1 and apolipoprotein E (ApoE) in the various stages of PC were assessed by immunohistochemistry, RT-PCR and western blotting. Additionally, the statistical significance of the results was analyzed. The expression levels of complement C3, complement C4b1 and apoE were higher in PC compared with normal pancreatic tissues. No correlations were observed between complement C3 and tumor TNM staging or lymph node metastasis. However, complement C4b1 and apoE were markedly correlated with tumor TNM staging and lymph node metastasis. Complement C3 may be used as a marker for the diagnosis of early-stage PC, while complement C4b1 and apoE are closely correlated with tumor development, reflecting the biological behavior of PC, and thus may be used as diagnostic markers of advanced PC.
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影响因子：
11.2
作者：
Moore LE;Brennan P;Karami S;Menashe I;Berndt SI;Dong LM;Meisner A;Yeager M;Chanock S;Colt J;Schwartz K;Davis F;Zaridze D;Mattveev V;Janout V;Kollarova H;Bencko V;Navratilova M;Szeszenia-Dabrowska N;Mates D;Holcatova I;Boffetta P;Chow WH;Rosenberg PS;Rothman N
通讯作者：
Rothman N
DOI：
10.1016/j.bbalip.2009.07.004
发表时间：
2009-12-01
影响因子：
4.8
作者：
Gillard, Baiba K.;Lin, Hu-Yu Alice;Pownall, Henry J.
通讯作者：
Pownall, Henry J.
影响因子：
3
作者：
Willett, CG;Daly, WJ;Warshaw, AL
通讯作者：
Warshaw, AL
影响因子：
--
作者：
Fujita, T;Hara, A;Yamazaki, Y
通讯作者：
Yamazaki, Y
影响因子：
7
作者：
Gronborg, M;Kristiansen, TZ;Pandey, A
通讯作者：
Pandey, A