Differences in candidate gene association between European ancestry and African American asthmatic children.
Differences in candidate gene association between European ancestry and African American asthmatic children.
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DOI：
10.1371/journal.pone.0016522
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发表时间：
2011-02-28
期刊：
影响因子：
3.7
通讯作者：
Khurana Hershey GK
中科院分区：
文献类型：
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作者：
Baye TM;Butsch Kovacic M;Biagini Myers JM;Martin LJ;Lindsey M;Patterson TL;He H;Ericksen MB;Gupta J;Tsoras AM;Lindsley A;Rothenberg ME;Wills-Karp M;Eissa NT;Borish L;Khurana Hershey GK
候选基因病例对照研究已经确定了几个与哮喘易感性相关的单核苷酸多态(SNPs)。这些研究大多局限于对单个基因和欧洲血统人群中特定SNPs的评估。最近，人们对了解与儿童哮喘相关的遗传风险的种族差异越来越感兴趣。我们的目的是比较欧洲和非洲血统的儿童之间哮喘候选基因的关联模式。使用定制设计的Illumina SNP阵列，我们对大辛辛那提儿科临床资料库和辛辛那提基因组控制队列中的1485名儿童进行了28个基因中259个SNP的基因分型，并评估了它们与哮喘的相关性。我们确定了位于6个基因中的14个SNPs与非裔美国人的儿童哮喘显著相关(p值为0.05)。在高加索人群中，5个基因中的13个SNPs与儿童哮喘相关。在两个种族中，IL4中的两个SNPs与哮喘相关(p<0.05)。基因-基因相互作用研究确定了最能区分哮喘儿童和非过敏性对照的种族特定基因组。我们发现IL4在非裔美国人和高加索儿童的哮喘易感性中都有作用。然而，尽管IL4 SNP与具有欧洲和非洲血统的哮喘儿童的哮喘有关，但复制最多的哮喘相关SNPs的相对贡献因血统而异。这些数据为欧洲血统与非洲血统的人易患哮喘的途径提供了有价值的见解。
Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry. Using a custom-designed Illumina SNP array, we genotyped 1,485 children within the Greater Cincinnati Pediatric Clinic Repository and Cincinnati Genomic Control Cohort for 259 SNPs in 28 genes and evaluated their associations with asthma. We identified 14 SNPs located in 6 genes that were significantly associated (p-values <0.05) with childhood asthma in African Americans. Among Caucasians, 13 SNPs in 5 genes were associated with childhood asthma. Two SNPs in IL4 were associated with asthma in both races (p-values <0.05). Gene-gene interaction studies identified race specific sets of genes that best discriminate between asthmatic children and non-allergic controls. We identified IL4 as having a role in asthma susceptibility in both African American and Caucasian children. However, while IL4 SNPs were associated with asthma in asthmatic children with European and African ancestry, the relative contributions of the most replicated asthma-associated SNPs varied by ancestry. These data provides valuable insights into the pathways that may predispose to asthma in individuals with European vs. African ancestry.
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影响因子：
14.2
作者：
Chinchilli, Vernon M.
通讯作者：
Chinchilli, Vernon M.
影响因子：
4.5
作者：
Baye TM;Tiwari HK;Allison DB;Go RC
通讯作者：
Go RC
影响因子：
14.2
作者：
Kabesch, M;Schedel, M;von Mutius, E
通讯作者：
von Mutius, E
影响因子：
5
作者：
Gauderman, WJ
通讯作者：
Gauderman, WJ
DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
1995-09-01
影响因子：
24.7
作者：
通讯作者：
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