Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation.
Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation.
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DOI：
10.3389/fcvm.2022.1045730
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
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肥胖是心房颤动 (AF) 的危险因素，强烈影响治疗反应。心房纤维化也显示出类似的关联。心外膜脂肪组织（EAT）可能是这些关联之间的联系。我们试图评估 EAT 是否与体重指数 (BMI)、左心房 (LA) 纤维化和体积相关。分别使用晚期钆增强和 Dixon MRI 序列评估 LA 纤维化和 EAT。我们导出了结合纤维化和 EAT 的 3D 模型，然后测量纤维化和非纤维化区域到最近 EAT 的距离，以评估空间共定位。对 103 名 AF 患者（64% 为阵发性，27% 为女性）进行了分析。 LA 体积指数为 54.9 (41.2, 69.7) mL/m2，LA EAT 指数为 17.4 (12.7, 22.9) mL/m2，LA 纤维化率为 17.1 (12.4, 23.1)%。 LA EAT 与 BMI 显着相关（R = 0.557，p < 0.001）；以及 BSA 调整后的 LA 体积和 LA 纤维化（分别为 R = 0.579 和 R = 0.432，两者的 p < 0.001）。多变量分析显示 LA EAT 与 LA 体积和纤维化独立相关。 LA 周围脂肪和纤维化的 3D 记录显示 EAT 和纤维化 LA 区域之间没有明显的空间重叠。 LA EAT 与肥胖 (BMI) 以及 LA 体积和纤维化相关。 LA EAT 区域并不与纤维化区域共定位，表明是系统性或旁分泌机制，而不是 EAT 对纤维化区域的浸润。
Obesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Epicardial adipose tissue (EAT) may be a link between these associations. We sought to assess whether EAT is associated with body mass index (BMI), left atrial (LA) fibrosis and volume. LA fibrosis and EAT were assessed using late gadolinium enhancement, and Dixon MRI sequences, respectively. We derived 3D models incorporating fibrosis and EAT, then measured the distance of fibrotic and non-fibrotic areas to the nearest EAT to assess spatial colocalization. One hundred and three AF patients (64% paroxysmal, 27% female) were analyzed. LA volume index was 54.9 (41.2, 69.7) mL/m2, LA EAT index was 17.4 (12.7, 22.9) mL/m2, and LA fibrosis was 17.1 (12.4, 23.1)%. LA EAT was significantly correlated with BMI (R = 0.557, p < 0.001); as well as with LA volume and LA fibrosis after BSA adjustment (R = 0.579 and R = 0.432, respectively, p < 0.001 for both). Multivariable analysis showed LA EAT to be independently associated with LA volume and fibrosis. 3D registration of fat and fibrosis around the LA showed no clear spatial overlap between EAT and fibrotic LA regions. LA EAT is associated with obesity (BMI) as well as LA volume and fibrosis. Regions of LA EAT did not colocalize with fibrotic areas, suggesting a systemic or paracrine mechanism rather than EAT infiltration of fibrotic areas.
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影响因子：
5.5
作者：
Abed, Hany S.;Samuel, Chrishan S.;Sanders, Prashanthan
通讯作者：
Sanders, Prashanthan
肉瘤蛋白滴定中的罕见截断变体与家族性和早期心房颤动相关。
影响因子：
16.6
作者：
Ahlberg G;Refsgaard L;Lundegaard PR;Andreasen L;Ranthe MF;Linscheid N;Nielsen JB;Melbye M;Haunsø S;Sajadieh A;Camp L;Olesen SP;Rasmussen S;Lundby A;Ellinor PT;Holst AG;Svendsen JH;Olesen MS
通讯作者：
Olesen MS
影响因子：
24
作者：
Mahajan, Rajiv;Lau, Dennis H.;Sanders, Prashanthan
通讯作者：
Sanders, Prashanthan
DOI：
10.1016/j.numecd.2017.05.009
发表时间：
2017-08-01
影响因子：
3.9
作者：
Fernandes-Cardoso, A.;Santos-Furtado, M.;Santo, M. A.
通讯作者：
Santo, M. A.
影响因子：
2.8
作者：
Khawaja, Tuba;Greer, Christine;Schulze, P. Christian
通讯作者：
Schulze, P. Christian