Antipsychotic utilisation and polypharmacy in Italian residential facilities: a survey
Antipsychotic utilisation and polypharmacy in Italian residential facilities: a survey
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意大利住宅设施中抗精神病药物的使用和复方用药：一项调查
DOI：
10.1017/s2045796011000242
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发表时间：
2011
影响因子：
8.1
通讯作者：
L. Ferrannini
中科院分区：
文献类型：
--
作者：
L. Ghio;W. Natta;S. Gotelli;L. Ferrannini
客观的。评估精神病院的处方实践，特别关注抗精神病药物的剂量和复方用药以及患者在机构内住宿期间抗精神病药物模式的变化。方法。其中包括意大利利古里亚地区的十五个住宅设施。数据是通过一日人口普查期间的图表审查收集的。估计精神治疗模式的频率。采用不同的非参数检验分析处方模式的变化以及抗精神病药物剂量、抗精神病药物数量与抗胆碱能药物使用之间的关系。结果。研究样本包括 362 名患者，其中 61.9% 为男性。普查当天，77.5% 的患者接受了精神药物联合治疗，57.2% 的患者接受了抗精神病药物联合治疗。抗精神病药物的多重用药与每日抗精神病药物的总剂量和抗胆碱能药物的使用有关。注意到在设施内停留期间抗精神病药物和精神药物的复方用药以及抗精神病药物剂量增加的趋势。这种趋势与在设施中停留的时间长短有关。结论。与相同临床环境中的早期研究相比，观察到精神药物和抗精神病药物的多药使用显着增加。服用多种药物的风险似乎与在机构中度过的时间有关。
Objective. To evaluate the prescribing practices in psychiatric residential facilities, with particular focus both on the antipsychotic dose and polypharmacy as well as the variation of antipsychotic patterns during a patient's stay within the facilities. Methods. Fifteen residential facilities of Liguria region in Italy were included. Data were collected through a chart review during a one-day census. Frequency of psychotropic patterns was estimated. Different non-parametric tests were used to analyse the changes in prescription patterns as well as the relationship among antipsychotic dose, the number of antipsychotics and anticholinergic use. Results. The study sample includes 362 patients, 61.9% males. On the census day 77.5% of patients received psychotropic polypharmacy and 57.2% antipsychotic polypharmacy. Antipsychotic polypharmacy was related to the total antipsychotic daily dose and to anticholinergic use. A trend towards an increase of antipsychotic and psychotropic polypharmacy and higher doses of antipsychotics over the period of stay within the facilities was noted. This tendency was related to the length of stay in the facility. Conclusions. Compared to earlier studies in the same clinical environment a significant increase in the use of psychotropic and antipsychotic polypharmacy was observed. The risk of prescribed polypharmacy seems to be related to time spent in the facility.
退伍军人事务部卫生系统中的长期抗精神病药物多药治疗：患者特征和治疗模式。
DOI：
10.1176/ps.2007.58.4.489
发表时间：
2007
期刊：
Psychiatric services (Washington, D.C.)
影响因子：
--
作者：
Kreyenbuhl,JulieA;Valenstein,Marcia;McCarthy,JohnF;Ganoczy,Dara;Blow,FredericC
通讯作者：
Blow,FredericC
影响因子：
5.3
作者：
Woods, SW
通讯作者：
Woods, SW
影响因子：
5.3
作者：
Ganguly, R;Kotzan, JA;Martin, BC
通讯作者：
Martin, BC