Investigation of an outbreak of symptomatic SARS-CoV-2 VOC 202012/01-lineage B.1.1.7 infection in healthcare workers, Italy.
Investigation of an outbreak of symptomatic SARS-CoV-2 VOC 202012/01-lineage B.1.1.7 infection in healthcare workers, Italy.
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DOI：
10.1016/j.cmi.2021.05.007
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Chironna M
中科院分区：
文献类型：
--
作者：
Loconsole D;Sallustio A;Accogli M;Leaci A;Sanguedolce A;Parisi A;Chironna M
2020年12月，意大利开始使用BNT 162 b2 2019冠状病毒病（COVID-19）mRNA疫苗开展全国免疫接种活动，优先接种医护人员（HCW）。来自接种疫苗受试者的免疫血清似乎（在很大程度上）保留了中和抗体的滴度，即使是针对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）VOC 202012/01-谱系B.1.1.7。在这里，我们描述了在医院环境中的三个HCW中爆发的SARS-CoV-2谱系B.1.1.7感染;其中两个HCW完全接种疫苗（即接受了两剂）。2021年2月20日同一班次的两名医生和一名护士参与了疫情。对SARS-CoV-2的IgG抗刺突蛋白进行了实时PCR、抗原检测和血清学检测，沿着全基因组测序（WGS）。三名医护人员均证实感染SARS-CoV-2，均出现轻微COVID-19症状。这两名医生完全接种了BNT 162 b2疫苗，在症状发作前1个月接种了第二剂。在诊断时，两人的IgG抗刺突抗体滴度均较高。WGS证实，所有病毒株均为VOC 202012/01-谱系B.1.1.7，表明存在共同的暴露源。流行病学调查显示，疑似来源为一名SARS-CoV-2阳性患者，该患者因严重COVID-19需要气管插管。所有程序均使用全套个人防护设备（PPE）进行。这次小规模爆发突出了一些重要问题，如疫苗对SARS-CoV-2变种传播的有效性、医务人员接触的高风险以及在医院优化实施PPE的必要性。VOC 20 2012/01在欧洲和意大利的广泛传播凸显了改善监测和基因测序的必要性。
In December 2020, Italy began a national immunization campaign using the BNT162b2 coronavirus disease 2019 (COVID-19) mRNA vaccine, prioritizing healthcare workers (HCWs). Immune serum from vaccinated subjects seems (largely) to retain titres of neutralizing antibodies, even against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) VOC 202012/01-lineage B.1.1.7. Here, we describe an outbreak of SARS-CoV-2 lineage B.1.1.7 infection in three HCWs in a hospital setting; two of the HCWs were fully vaccinated (i.e. had received two doses). Two physicians and one nurse working on the same shift on 20th February 2021 were involved in the outbreak. Real-time PCR, antigen tests, and serological tests for the IgG anti-spike protein of SARS-CoV-2 were performed, along with whole-genome sequencing (WGS). SARS-CoV-2 infection was confirmed in all three HCWs; all presented with mild symptoms of COVID-19. The two physicians were fully vaccinated with BNT162b2 vaccine, with the second dose administered 1 month before symptom onset. Both had high titres of IgG anti-spike antibodies at the time of diagnosis. WGS confirmed that all virus strains were VOC 202012/01-lineage B.1.1.7, suggesting a common source of exposure. Epidemiological investigation revealed that the suspected source was a SARS-CoV-2-positive patient who required endotracheal intubation due to severe COVID-19. All procedures were carried out using a full suite of personal protective equipment (PPE). This mini-outbreak highlights some important issues about the efficacy of vaccines against transmission of SARS-CoV-2 variants, the high risk of exposure among HCWs, and the need for optimized implementation of PPE in hospitals. The wide circulation of VOC 202012/01 in Europe and Italy highlights the need to improve surveillance and genetic sequencing.
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DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
0.8
作者：
Loconsole D;Sallustio A;Accogli M;Centrone F;Capozzi L;Del Sambro L;Parisi A;Chironna M
通讯作者：
Chironna M
DOI：
10.1126/science.abg6105
发表时间：
2021-03-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Muik A;Wallisch AK;Sänger B;Swanson KA;Mühl J;Chen W;Cai H;Maurus D;Sarkar R;Türeci Ö;Dormitzer PR;Şahin U
通讯作者：
Şahin U
DOI：
10.1056/nejmoa2101765
发表时间：
2021-04-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Dagan N;Barda N;Kepten E;Miron O;Perchik S;Katz MA;Hernán MA;Lipsitch M;Reis B;Balicer RD
通讯作者：
Balicer RD