Next generation natural killer cells for cancer immunotherapy: the promise of genetic engineering.
Next generation natural killer cells for cancer immunotherapy: the promise of genetic engineering.
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DOI：
10.1016/j.coi.2018.03.013
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发表时间：
2018-04
影响因子：
7
通讯作者：
Rezvani K
中科院分区：
文献类型：
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作者：
Daher M;Rezvani K
细胞治疗领域的最新进展集中在工程化以表达针对肿瘤抗原的嵌合抗原受体（CAR）的自体T细胞。在接受自体CD19重定向T细胞治疗B淋巴恶性肿瘤的患者中观察到显著的应答。然而，为每个患者生成自体产物在后勤上是具有挑战性的并且昂贵的。正在进行广泛的研究工作，以产生用于治疗癌症患者的现成细胞产品。自然杀伤细胞（NK）是有吸引力的竞争者，因为它们具有有效的抗肿瘤活性，并且它们在同种异体环境中的安全性消除了对自体来源的需要。在这篇综述中，我们讨论了NK细胞治疗的优点和局限性，以及可能用于克服某些局限性的新型基因工程策略。下一代工程化NK细胞在临床前环境中显示出巨大的前景，并且很可能在未来几年内CAR工程化NK细胞将被纳入目前基于细胞的癌症治疗的设备中。
Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19- redirected T cells for the treatment B-lymphoid malignancies. However, the generation of autologous products for each patient is logistically challenging and expensive. Extensive research efforts are ongoing to generate an off-the-shelf cellular product for the treatment of cancer patients. Natural killer cells (NK) are attractive contenders since they have potent anti-tumor activity, and their safety in the allogeneic setting obviates the need for an autologous source. In this review, we discuss advantages and limitations of NK cellular therapy, and novel genetic engineering strategies that may be applied to overcome some of the limitations. Next-generation engineered NK cells are showing great promise in the preclinical setting and it is likely that in the next few years CAR- engineered NK cells will be incorporated into the current armamentarium of cell-based cancer therapeutics.
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影响因子：
10.9
作者：
Kremer V;Ligtenberg MA;Zendehdel R;Seitz C;Duivenvoorden A;Wennerberg E;Colón E;Scherman-Plogell AH;Lundqvist A
通讯作者：
Lundqvist A
影响因子：
7.3
作者：
Klingemann H;Boissel L;Toneguzzo F
通讯作者：
Toneguzzo F
影响因子：
4.7
作者：
Figueiredo, Constanca;Seltsam, Axel;Blasczyk, Rainer
通讯作者：
Blasczyk, Rainer
影响因子：
11.2
作者：
Chang, Yu-Hsiang;Connolly, John;Campana, Dario
通讯作者：
Campana, Dario
影响因子：
28.2
作者：
通讯作者：
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