Antimicrobial second skin using copper nanomesh.
Antimicrobial second skin using copper nanomesh.
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DOI：
10.1073/pnas.2200830119
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发表时间：
2022-06-14
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
最近的COVID-19大流行需要长期和现实生活中适用的抗菌皮肤保护。然而，还没有实际的解决方案来防止交叉感染，同时保持内在的皮肤自然性。传统的基于阻塞的方法，如手套，不能保持皮肤无菌性，并改变影响我们感觉和舒适度的形态、温度变化率和湿度。在这里，我们提出了一种皮肤可附着的保护平台铜纳米网，它可以防止交叉感染，同时保持皮肤的自然性。由铜涂层和互连的聚合物纳米纤维组成的铜纳米网在1和10分钟内杀死99.99%的细菌和病毒，并防止细菌交叉感染。与薄膜或手套相比，纳米网的薄且多孔的结构能够在形态、温度变化率和湿度方面实现自然的皮肤-环境相互作用。生物工程的最终目标之一是在保持固有自然性的同时，为我们的身体提供功能支持和进步。针对感染性病原体的皮肤保护是一种需要普通和长期佩戴而不会出现不适或皮肤功能扭曲的应用。然而，还没有引入抗菌方法来防止交叉感染，同时保持内在的皮肤状况。在这里，我们提出了一种抗菌皮肤保护平台铜纳米网，它可以防止交叉感染，包括皮肤表面形态、温度变化率和皮肤湿度。铜纳米网在1和10 min内对大肠杆菌和流感病毒A的灭活率分别为99.99%。薄且多孔的纳米网允许在指尖上进行保形涂层，而不会显著干扰皮肤温度变化和湿度的速率。铜纳米网的有效交叉感染预防和热传递使用直接的现场实验证明。
The recent COVID-19 pandemic requires long-term and real-life applicable antimicrobial skin protection. However, there has been no practical solution to prevent cross-infection while preserving intrinsic skin naturalness. Conventional blocking-based approaches such as gloves cannot preserve the skin sterility and modify the morphology, temperature change rate, and humidity affecting our sensation and comfort. Here, we propose a skin-attachable protection platform copper nanomesh, which prevents cross-infection while maintaining skin naturalness. Copper nanomesh composed of copper coating and interconnected polymer nanofibers kills 99.99% of bacteria and viruses within 1 and 10 min and prevents bacterial cross-infection. The thin and porous structure of the nanomesh enables natural skin-environment interaction in terms of the morphology, temperature change rate, and humidity compared to films or gloves. The functional support and advancement of our body while preserving inherent naturalness is one of the ultimate goals of bioengineering. Skin protection against infectious pathogens is an application that requires common and long-term wear without discomfort or distortion of the skin functions. However, no antimicrobial method has been introduced to prevent cross-infection while preserving intrinsic skin conditions. Here, we propose an antimicrobial skin protection platform copper nanomesh, which prevents cross-infectionmorphology, temperature change rate, and skin humidity. Copper nanomesh exhibited an inactivation rate of 99.99% for Escherichia coli bacteria and influenza virus A within 1 and 10 min, respectively. The thin and porous nanomesh allows for conformal coating on the fingertips, without significant interference with the rate of skin temperature change and humidity. Efficient cross-infection prevention and thermal transfer of copper nanomesh were demonstrated using direct on-hand experiments.
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