Evolving concepts of tumor heterogeneity.
Evolving concepts of tumor heterogeneity.
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DOI：
10.1186/2045-3701-4-69
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发表时间：
2014
影响因子：
7.5
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Zellmer VR;Zhang S
过去和最近关于肿瘤异质性的发现使临床医生和研究人员将癌症发展广泛定义为一个不断演变的过程。这种肿瘤发生的进化模型在很大程度上是由赋予恶性细胞表型的健身促进突变的开创性报告形成的。尽管研究遗传异质性带来了重大的临床和智力进步，但长期以来一直被忽视的是，组成肿瘤异质性和肿瘤微环境（TME）诱导的选择压力驱动肿瘤进化，对肿瘤发展和临床癌症治疗的结果有重要贡献。在这篇综述中，我们试图总结肿瘤演变中的主要里程碑，确定TME依赖性演变背景下肿瘤异质性的关键方面，并就研究人员和临床医生面临的临床挑战提供见解。
Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped by seminal reports of fitness-promoting mutations conferring a malignant cellular phenotype. Despite the major clinical and intellectual advances that have resulted from studying heritable heterogeneity, it has long been overlooked that compositional tumor heterogeneity and tumor microenvironment (TME)-induced selection pressures drive tumor evolution, significantly contributing to tumor development and outcomes of clinical cancer treatment. In this review, we seek to summarize major milestones in tumor evolution, identify key aspects of tumor heterogeneity in a TME-dependent evolutionary context, and provide insights on the clinical challenges facing researchers and clinicians alike.
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影响因子：
45.3
作者：
Coombs, NJ;Boyages, J
通讯作者：
Boyages, J
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.6
作者：
Agus, David B.;Alexander, Jenolyn F.;Arap, Wadih;Ashili, Shashanka;Aslan, Joseph E.;Austin, Robert H.;Backman, Vadim;Bethel, Kelly J.;Bonneau, Richard;Chen, Wei-Chiang;Chen-Tanyolac, Chira;Choi, Nathan C.;Curley, Steven A.;Dallas, Matthew;Damania, Dhwanil;Davies, Paul C. W.;Decuzzi, Paolo;Dickinson, Laura;Estevez-Salmeron, Luis;Estrella, Veronica;Ferrari, Mauro;Fischbach, Claudia;Foo, Jasmine;Fraley, Stephanie I.;Frantz, Christian;Fuhrmann, Alexander;Gascard, Philippe;Gatenby, Robert A.;Geng, Yue;Gerecht, Sharon;Gillies, Robert J.;Godin, Biana;Grady, William M.;Greenfield, Alex;Hemphill, Courtney;Hempstead, Barbara L.;Hielscher, Abigail;Hillis, W. Daniel;Holland, Eric C.;Ibrahim-Hashim, Arig;Jacks, Tyler;Johnson, Roger H.;Joo, Ahyoung;Katz, Jonathan E.;Kelbauskas, Laimonas;Kesselman, Carl;King, Michael R.;Konstantopoulos, Konstantinos;Kraning-Rush, Casey M.;Kuhn, Peter;Kung, Kevin;Kwee, Brian;Lakins, Johnathon N.;Lambert, Guillaume;Liao, David;Licht, Jonathan D.;Liphardt, Jan T.;Liu, Liyu;Lloyd, Mark C.;Lyubimova, Anna;Mallick, Parag;Marko, John;McCarty, Owen J. T.;Meldrum, Deirdre R.;Michor, Franziska;Mumenthaler, Shannon M.;Nandakumar, Vivek;O'Halloran, Thomas V.;Oh, Steve;Pasqualini, Renata;Paszek, Matthew J.;Philips, Kevin G.;Poultney, Christopher S.;Rana, Kuldeepsinh;Reinhart-King, Cynthia A.;Ros, Robert;Semenza, Gregg L.;Senechal, Patti;Shuler, Michael L.;Srinivasan, Srimeenakshi;Staunton, Jack R.;Stypula, Yolanda;Subramanian, Hariharan;Tlsty, Thea D.;Tormoen, Garth W.;Tseng, Yiider;van Oudenaarden, Alexander;Verbridge, Scott S.;Wan, Jenny C.;Weaver, Valerie M.;Widom, Jonathan;Will, Christine;Wirtz, Denis;Wojtkowiak, Jonathan;Wu, Pei-Hsun
通讯作者：
Wu, Pei-Hsun
DOI：
10.1073/pnas.1102454108
发表时间：
2011-05-10
影响因子：
11.1
作者：
Chaffer, Christine L.;Brueckmann, Ines;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.