A histological study of scala communis with radiological implications.
A histological study of scala communis with radiological implications.
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DOI：
10.1159/000307345
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发表时间：
2010
影响因子：
1.6
通讯作者：
Merchant S
中科院分区：
文献类型：
--
作者：
Makary C;Shin J;Caruso P;Curtin H;Merchant S
总阶或阶间隔膜（IS）缺陷是内耳的发育异常，其特征在于分离耳蜗匝的分隔物中的裂开。本研究的目的是（1）研究这种异常，并使用颞骨的组织学分析与对照耳相比描述其特征，（2）讨论其诊断的放射学意义，（3）描述其胚胎学起源。在评估的1775个颞骨中，发现22个标本在耳蜗中具有包含所有3个转弯（基底、中间和顶端）的总阶。采用光学显微镜对这22耳进行了详细的定性和定量研究。共阶是一种孤立的内耳异常，或与其他先天性耳蜗和/或前庭异常相关。缺损最常发生在耳蜗的中回和顶回之间。与对照耳相比，发现总阶耳具有较小的蜗轴面积（p < 0.0001）和阶间脊（IS与耳蜗内腔的附着点; p < 0.0001）的平坦化。共阶与正常听力相容。在CT扫描中，阶间嵴变平有可能提高对患者总阶的诊断。这种异常可能是由于中胚层缺陷，如在骨阶形成过程中间充质的过度吸收，骨形成错误，或两者兼而有之。
Scala communis or interscalar septum (IS) defect is a developmental abnormality of the inner ear characterized by a dehiscence in the partition separating the turns of the cochlea. The goals of the present study were to (1) study this anomaly and describe its characteristics compared to control ears using a histological analysis of temporal bones, (2) discuss radiological implications regarding its diagnosis, and (3) describe its embryological derivation. Out of 1775 temporal bones assessed, 22 specimens were found to have scala communis in cochleae containing all 3 turns (basal, middle and apical). These 22 ears were studied in detail by qualitative and quantitative methods using light microscopy. Scala communis occurred as an isolated inner ear anomaly, or in association with other congenital cochlear and/or vestibular anomalies. The defect occurred most often between the middle and apical turns of the cochlea. Compared to control ears, scala communis ears were found to have a smaller modiolar area (p < 0.0001) and flattening of the interscalar ridge (point of attachment of the IS to the inner lumen of the cochlea; p < 0.0001). Scala communis was compatible with normal hearing. Flattening of the interscalar ridge has the potential to improve the diagnosis of scala communis in patients using CT scanning. The anomaly may result from a mesodermal defect such as excessive resorption of mesenchyme during the formation of the scalae, an error in the formation of bone, or both.
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影响因子：
2.1
作者：
Sennaroglu, L;Saatci, T
通讯作者：
Saatci, T
DOI：
10.1016/s0165-5876(01)00642-5
发表时间：
2002-03-15
影响因子：
1.5
作者：
Zheng, YQ;Schachern, PA;Paparella, MM
通讯作者：
Paparella, MM
DOI：
10.3109/00016483109119096
发表时间：
1931-01-01
期刊：
ACTA OTO LARYNGOL
影响因子：
--
作者：
GUILD, STACY R.;CROWE, S. J.;POLVOGT, L. M.
通讯作者：
POLVOGT, L. M.
影响因子：
--
作者：
Streeter, GL
通讯作者：
Streeter, GL
影响因子：
2.6
作者：
Sennaroglu, L;Saatci, I
通讯作者：
Saatci, I