Higher parity is associated with an increased risk of type-II diabetes in Chinese women: the Singapore Chinese Health Study.
Higher parity is associated with an increased risk of type-II diabetes in Chinese women: the Singapore Chinese Health Study.
复制标题
较高的平价与中国女性II型糖尿病的风险增加有关：新加坡中国卫生研究。
DOI：
10.1111/1471-0528.12364
复制
发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Pereira MA
中科院分区：
文献类型：
--
作者：
Mueller NT;Mueller NJ;Odegaard AO;Gross MD;Koh WP;Yuan JM;Pereira MA
产次与II型糖尿病之间的关系主要在西方人群中进行研究，结果并不一致。在这里，我们研究是否奇偶校验与新加坡华人妇女的II型糖尿病事件呈正相关。前瞻性队列研究。新加坡。共有25021名来自新加坡华人健康研究的45 - 74岁新加坡华人女性，基线时（1993 - 1998年）无癌症、心脏病、中风和糖尿病。2004年，对女性糖尿病事件进行了随访。计算不同胎次（活产）类别的II型糖尿病风险比，并根据基线年龄、访问年份、方言、教育、吸烟、饮食模式、体力活动、初潮年龄、口服避孕药使用、绝经状态、激素治疗使用和体重指数（BMI）进行调整。自我报告的糖尿病，由医生诊断。在平均5.7人年的随访中，1294名女性被诊断患有糖尿病。在多变量校正前后，产次与II型糖尿病风险之间存在正相关（P <0.001）。在包括成人BMI的完全校正模型中，与没有活产的妇女相比，有一个或两个，三个或四个和五个或更多活产的妇女患II型糖尿病的风险分别增加了31%（从-2%至76%），62%（从22%至116%）和74%（从29%至133%）。此外，在非糖尿病女性的补充多变量分析中，我们发现产次与糖化血红蛋白（HbA1c）之间存在正单调相关（P = 0.01）。产次增加可能是中国女性II型糖尿病的危险因素。需要对生活方式和生理因素进行更多的研究，以解释这种关联。
The association between parity and type-II diabetes has been studied primarily in Western populations, and the findings have been inconsistent. Here, we examine whether parity was positively associated with incident type-II diabetes in Singaporean Chinese women. Prospective cohort study. Singapore. A total of 25 021 Singaporean Chinese women aged 45–74 years from the Singapore Chinese Health Study who were free of cancer, heart disease, stroke, and diabetes at baseline (1993–1998). Women were followed through 2004 for incident diabetes. Hazard ratios for type-II diabetes were computed across parity (of live births) categories and adjusted for baseline age, interview year, dialect, education, smoking, dietary pattern, physical activity, age at menarche, oral contraceptive use, menopausal status, hormone therapy use, and body mass index (BMI). Self-reported diabetes, as diagnosed by a doctor. Over an average of 5.7 person-years of follow-up, 1294 women were diagnosed with diabetes. Before and after multivariable adjustment there was a positive graded association between parity and type-II diabetes risk (P < 0.001). In the fully adjusted model, which included adult BMI, the risk of type-II diabetes increased by 31% (from −2 to 76%), 62% (from 22 to 116%), and 74% (from 29 to 133%) for women with one or two, three or four, and five or more live births, respectively, compared with women with no live births. Moreover, in a supplementary multivariate analysis in non-diabetic women we found a positive monotonic association between parity and glycated haemoglobin (HbA1c) (P = 0.01). Increased parity may be a risk factor for type-II diabetes in Chinese women. More research is needed on lifestyle and physiologic factors that may explain this association.
登录
查看更多内容
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
16.2
作者：
Fowler-Brown AG;de Boer IH;Catov JM;Carnethon MR;Kamineni A;Kuller LH;Siscovick DS;Mukamal KJ
通讯作者：
Mukamal KJ
影响因子：
16.2
作者：
COLLINS, VR;DOWSE, GK;ZIMMET, PZ
通讯作者：
ZIMMET, PZ
DOI：
10.1136/bmj.e2088
发表时间：
2012-05-16
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Thangaratinam S;Rogozinska E;Jolly K;Glinkowski S;Roseboom T;Tomlinson JW;Kunz R;Mol BW;Coomarasamy A;Khan KS
通讯作者：
Khan KS
影响因子：
16.2
作者：
BOYKO, EJ;ALDERMAN, BW;BARON, AE
通讯作者：
BARON, AE