Nitric oxide-cyclic GMP signaling in stem cell differentiation.
Nitric oxide-cyclic GMP signaling in stem cell differentiation.
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DOI：
10.1016/j.freeradbiomed.2011.09.037
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发表时间：
2011-12-15
影响因子：
7.4
通讯作者：
Murad, Fend
中科院分区：
文献类型：
--
作者：
Mujoo, Kalpana;Krumenacker, Joshua S.;Murad, Fend
一氧化氮-环鸟苷酸（NO-cGMP）途径介导与包括心血管和神经系统在内的各种综合身体系统相关的重要生理功能。此外，NO在细胞水平上调节细胞生长、存活、凋亡、增殖和分化。为了了解NO-cGMP途径在发育和分化中的重要性，已经在发育中的胚胎和干细胞中进行了研究。通过采用活化剂和抑制剂作为药理学探针和/或NO信号传导组分的遗传操作来操纵NO-cGMP途径，已经暗示了该途径参与干细胞分化的调节。本文将重点介绍NO-cGMP在干细胞分化为不同谱系细胞，特别是心肌细胞和干细胞治疗中的作用。
The nitric oxide-cyclic GMP (NO-cGMP) pathway mediates important physiological functions associated with various integrative body systems including the cardiovascular and nervous systems. Furthermore, NO regulates cell growth, survival, apoptosis, proliferation and differentiation at the cellular level. To understand the significance of the NO-cGMP pathway in development and differentiation, studies have been conducted both in developing embryos and stem cells. Manipulation of the NO-cGMP pathway by employing activators and inhibitors as pharmacological probes and/or genetic manipulation of NO signaling components has implicated the involvement of this pathway in regulation of stem cell differentiation. This review will focus on some of the work pertaining to the role of NO-cGMP in differentiation of stem cells into cells of various lineages particularly into myocardial cells and stem cell based therapy.
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影响因子：
46.9
作者：
Deng, Jie;Shoemaker, Robert;Xie, Bin;Gore, Athurva;LeProust, Emily M.;Antosiewicz-Bourget, Jessica;Egli, Dieter;Maherali, Nimet;Park, In-Hyun;Yu, Junying;Daley, George Q.;Eggan, Kevin;Hochedlinger, Konrad;Thomson, James;Wang, Wei;Gao, Yuan;Zhang, Kun
通讯作者：
Zhang, Kun
影响因子：
3.1
作者：
Boyum, A;Fjerdingstad, HB;Lovhaug, D
通讯作者：
Lovhaug, D
影响因子：
11.4
作者：
Aszódi, A;Pfeifer, A;Fässler, R
通讯作者：
Fässler, R
影响因子：
82.9
作者：
Aicher, A;Heeschen, C;Dimmeler, S
通讯作者：
Dimmeler, S
DOI：
10.1073/pnas.96.13.7553
发表时间：
1999-06-22
影响因子：
11.1
作者：
Biel, M;Seeliger, M;Hofmann, F
通讯作者：
Hofmann, F