Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study.
Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study.
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症状的持续时间与疾病严重程度在第一次出现到小儿风湿病学：儿童期关节炎前瞻性研究的结果。
DOI：
10.1093/rheumatology/ken085
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发表时间：
2008-07
期刊：
影响因子：
5.5
通讯作者：
Thomson, W.
中科院分区：
文献类型：
--
作者：
Adib, N.;Hyrich, K.;Thornton, J.;Lunt, M.;Davidson, J.;Gardner-Medwin, J.;Foster, H.;Baildam, E.;Wedderburn, L.;Thomson, W.
关键词：
目标.研究儿童关节炎前瞻性研究招募的儿童中首次出现儿科风湿病（PRh）时的疾病严重程度与症状发作时间长度之间的相关性。方法.从5家英国医院招募了患有持续≥2周的炎性关节炎的≤16岁儿童。在第一次PRh预约时（基线）收集数据，包括人口统计学、疾病特征、儿童健康评估问卷（CHAQ）、医生和父母的总体评估和血液检查。使用非参数描述性统计和多变量logistic回归分析评价症状持续时间（定义为首次报告症状发作至PRh出现的时间）与基线疾病特征之间的相关性。结果纳入507名儿童（65%为女性）：发病时的中位年龄为6.8岁。233名患有少关节炎，68名患有RF阴性多关节炎，27名患有全身性关节炎，29名患有非JIA关节炎。中位症状持续时间为4.6个月。中位症状持续时间最短的儿童表现为全身性关节炎（1.6个月）和最长的PsA（8.6个月）。症状持续时间较长的儿童年龄较大，活动关节数中位数较高，但ESR中位数较低。症状持续时间与就诊时CHAQ评分无关。结论.患有全身性关节炎的儿童PRh延迟时间最短，可能是因为他们非常不适。有关节疼痛/僵硬但ESR正常的儿童有较长的延迟，这表明如果血液检查没有表明炎症，JIA的诊断可能会被忽视。
Objectives. To study the association between disease severity at first presentation to paediatric rheumatology (PRh) and length of time since symptom onset in children recruited to the Childhood Arthritis Prospective Study. Methods. Children ≤16 yrs with inflammatory arthritis persisting ≥2 weeks were recruited from five UK hospitals. Data including demographics, disease features, Childhood Health Assessment Questionnaire (CHAQ), physician and parent global assessment and blood tests were collected at the first appointment with PRh (baseline). The association between symptom duration (defined as time from first reported symptom onset to presentation at PRh) and baseline disease characteristics was evaluated using non-parametric descriptive statistics and multivariable logistic regression analyses. Results. Five hundred and seven children (65% female) were included: median age at onset was 6.8 yrs. Two hundred and thirty-three had oligoarthritis, 68 had RF-negative polyarthritis, 27 had systemic onset arthritis and 29 had arthritis that was not JIA. The median symptom duration was 4.6 months. Median symptom duration was shortest for children presenting with systemic arthritis (1.6 months) and longest for those with PsA (8.6 months). Children with a longer duration of symptoms were older and had higher median active joint counts but lower median ESR. Symptom duration did not correlate with CHAQ score at presentation. Conclusions. Children who have systemic arthritis had the shortest delay to PRh presumably because they are profoundly unwell. Children with joint pain/stiffness but normal ESR had longer delays suggesting that if blood tests do not indicate inflammation, the diagnosis of JIA may be overlooked.
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DOI：
10.1002/art.22230
发表时间：
2006-10-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Foster, H. E.;Kay, L. J.;Myers, A.
通讯作者：
Myers, A.
影响因子：
--
作者：
Vollmann, J;Winau, R
通讯作者：
Winau, R
影响因子：
5.5
作者：
Luqmani, R.;Hennell, S.;Webb, F.
通讯作者：
Webb, F.
影响因子：
11.4
作者：
Manners, PJ
通讯作者：
Manners, PJ
DOI：
10.1002/art.21983
发表时间：
2006-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Len, CA;Terreri, MT;Hil치rio, MOE
通讯作者：
Hil치rio, MOE