Ontogeny of mechanisms which regulate light/dark differences in retinal dopamine synthesis.
Ontogeny of mechanisms which regulate light/dark differences in retinal dopamine synthesis.
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调节视网膜多巴胺合成中光/暗差异的机制的个体发育。
DOI：
10.1016/0014-2999(84)90160-2
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发表时间：
1984
影响因子：
5
通讯作者：
Morgan,WW
中科院分区：
文献类型：
--
作者：
Kamp,CW;Morgan,WW
研究了GABA拮抗剂双库兰（bicuculline）在大鼠睁眼后1、4、7、15和60天促进视网膜多巴胺（DA）合成的能力，并与光诱导的DA合成增加的出生后发育的时间过程进行了比较。使用l -芳香氨基酸脱羧酶抑制剂NSD 1015后，二羟基苯丙氨酸（DOPA）的积累被用来估计DA的合成。在适应黑暗的大鼠中，双管碱和光照均未增加睁眼后1天的多巴积累，但在其余几天中，两种处理均显著增加了DA合成，到第15天，效果与成人视网膜一样大。在每个时间点，药物在黑暗中对DA合成的影响程度与在光照下观察到的相似。这些结果表明，DA神经元的内源性gaba能输入与多巴胺能对光的反应获得同时出现。我们还评估了双球茎碱处理对光暴露动物DA合成的影响。在第4天和第7天，该药明显增加了DOPA的积累，而在后来的几天，二胡兰没有这种加性作用。这些数据表明，在光反应机制成熟的早期，而不是抑制性gaba能张力的去除，可能是DA神经元兴奋的部分原因。
The ability of bicuculline, a GABA antagonist, to enhance dopamine (DA) synthesis in retinas of rats 1, 4, 7, 15 and 60 days after eye opening was assessed and compared to the time course of postnatal development of the light-induced increase in DA synthesis. The accumulation of dihydroxyphenylalanine (DOPA) following administration of the L-aromatic amino acid decarboxylase inhibitor, NSD 1015, was used to estimate DA synthesis. In dark-adapted rats, neither bicuculline nor light enhanced DOPA accumulation 1 day after eye opening, but on the remaining days either treatment significantly augmented DA synthesis, and by day 15 effects were as great as those observed in adult retinas. At each time point, the magnitude of the drug effect on DA synthesis in the dark was similar to that observed following light exposure. These results suggest that an endogenous GABAergic inout to the DA neurons appears at the same time as the acquisition of the dopaminergic response to light. The effect of bicuculline treatment on DA synthesis in light-exposed animals was also assessed. At 4 and 7 days the drug significantly enhanced DOPA accumulation over that produced by exposure to light alone, but on later days bicuculline exerted no such additive effect. These data imply that early in the maturation of the light response mechanisms other than removal of an inhibitory GABAergic tone may be partially responsible for excitation of the DA neurons.
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兔视网膜和脉络膜中儿茶酚胺的鉴定和细胞定位。
DOI：
10.1111/j.1748-1716.1965.tb04153.x
发表时间：
1965
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
J. Häggendal;T. Malmfors
通讯作者：
T. Malmfors
GABA 拮抗剂可增强大鼠体内视网膜的多巴胺周转。
影响因子：
5
作者：
C. Kamp;W. W. Morgan
通讯作者：
W. W. Morgan
GABA 能对暗适应大鼠体内光诱导多巴胺周转增加的影响
影响因子：
4.7
作者：
W. W. Morgan;C. Kamp
通讯作者：
C. Kamp
兴奋性氨基酸对大鼠视网膜多巴胺合成的影响。
影响因子：
5
作者：
Kamp,CW;Morgan,WW
通讯作者：
Morgan,WW
光和暗对视网膜和脉络膜儿茶酚胺含量的影响。
DOI：
--
发表时间：
1967
期刊：
Investigative Ophthalmology
影响因子：
--
作者：
C. Nichols;D. Jacobowitz;M. Hottenstein
通讯作者：
M. Hottenstein