Beyond the horizon: Neutrophils leading the way in the evolution of immunotherapy.
Beyond the horizon: Neutrophils leading the way in the evolution of immunotherapy.
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癌症是一种复杂和动态的疾病，由许多内在突变引发，并在组织微环境的帮助下进展，由包括免疫细胞浸润在内的基质细胞包围。肿瘤可以逃避抗癌免疫功能的新发现塑造了免疫治疗领域，这是治疗癌症的革命性方法。然而，主要靶向T细胞的免疫治疗方法的发展，如免疫检查点抑制，也带来了证据的积累，证明了肿瘤进展的其他免疫细胞驱动因素，如先天免疫细胞，特别是中性粒细胞。在过去的十年中，中性粒细胞已经成为多种癌症类型的主要介质，甚至在最近几年，由于其在下一代免疫疗法中的潜在用途而受到关注。在这里，我们回顾了当前的免疫治疗策略，并深入讨论了中性粒细胞在癌症中的作用以及治疗癌症的新型中性粒细胞靶向方法。中性粒细胞在肿瘤微环境（TME）中的作用。全面概述了TME中中性粒细胞和癌细胞之间的复杂关系。该图显示了中性粒细胞募集的过程，并强调了它们在TME中的重要功能，这些功能可能是促肿瘤或抗肿瘤的，包括产生活性氧（ROS）、中性粒细胞胞外陷阱（NET）、脱粒、吞噬作用、介导抗体依赖性细胞毒性（ADCC）以及中性粒细胞在适应性免疫激活中的新兴作用。
Cancer is a complex and dynamic disease, initiated by a multitude of intrinsic mutations and progressed with the assistance of the tissue microenvironment, encompassed by stromal cells including immune cell infiltration. The novel finding that tumors can evade anti‐cancer immune functions shaped the field of immunotherapy, which has been a revolutionary approach for the treatment of cancers. However, the development of predominantly T cell‐targeted immunotherapy approaches, such as immune checkpoint inhibition, also brought about an accumulation of evidence demonstrating other immune cell drivers of tumor progression, such as innate immune cells and notably, neutrophils. In the past decade, neutrophils have emerged to be primary mediators of multiple cancer types and even in recent years, are gaining attention for their potential use in the next generation of immunotherapies. Here, we review current immunotherapy strategies and thoroughly discuss the roles of neutrophils in cancer and novel neutrophil‐targeted methods for treating cancer. Roles of neutrophils in the tumor microenvironment (TME). A comprehensive overview of the intricate relationship between neutrophils and cancer cells in the TME. This figure shows the process of neutrophil recruitment and highlights their vital functions in the TME which may be both pro‐ or anti‐tumorigenic, including the production of reactive oxygen species (ROS), neutrophil extracellular traps (NETs), degranulation, phagocytosis, mediating antibody‐dependent cellular cytotoxicity (ADCC), and the emerging roles of neutrophils in the activation of adaptive immunity.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
DOI：
10.1038/s41571-021-00546-5
发表时间：
2021-12
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Chen Y;McAndrews KM;Kalluri R
通讯作者：
Kalluri R
影响因子：
4.5
作者：
Blanter M;Gouwy M;Struyf S
通讯作者：
Struyf S
影响因子：
6
作者：
Bekes, Erin M.;Schweighofer, Bernhard;Deryugina, Elena I.
通讯作者：
Deryugina, Elena I.
影响因子：
4
作者：
Costanzo-Garvey, Diane L.;Case, Adam J.;Watson, Gabrielle F.;Alsamraae, Massar;Chatterjee, Arpita;Oberley-Deegan, Rebecca E.;Dutta, Samikshan;Abdalla, Maher Y.;Kielian, Tammy;Lindsey, Merry L.;Cook, Leah M.
通讯作者：
Cook, Leah M.