Mitochondria as a potential regulator of myogenesis.
Mitochondria as a potential regulator of myogenesis.
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DOI：
10.1155/2013/593267
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发表时间：
2013
影响因子：
--
通讯作者：
Sakuma K
中科院分区：
文献类型：
--
作者：
Wagatsuma A;Sakuma K
近年来的研究表明，线粒体在肌肉形成的调控中起着重要作用。事实上，当成肌细胞分化为肌管时，线粒体的丰度、形态和功能特性都发生了改变。例如，线粒体质量/体积、mtDNA拷贝数和线粒体呼吸在肌源性分化开始后显著增加。此外，线粒体酶活性也增加，这表明在肌分化过程中，代谢从糖酵解向氧化磷酸化转变为主要的能量来源。一些证据表明，线粒体功能和活动的损害阻碍了肌源性分化。然而，我们对线粒体调控肌肉形成的分子机制知之甚少。了解线粒体如何参与肌肉形成将为了解调节细胞稳态维持的潜在机制提供有价值的见解。在这里，我们将总结目前关于线粒体作为肌生成的潜在调节剂的作用的知识。
Recent studies have shown that mitochondria play a role in the regulation of myogenesis. Indeed, the abundance, morphology, and functional properties of mitochondria become altered when the myoblasts differentiate into myotubes. For example, mitochondrial mass/volume, mtDNA copy number, and mitochondrial respiration are markedly increased after the onset of myogenic differentiation. Besides, mitochondrial enzyme activity is also increased, suggesting that the metabolic shift from glycolysis to oxidative phosphorylation as the major energy source occurs during myogenic differentiation. Several lines of evidence suggest that impairment of mitochondrial function and activity blocks myogenic differentiation. However, yet little is known about the molecular mechanisms underlying the regulation of myogenesis by mitochondria. Understanding how mitochondria are involved in myogenesis will provide a valuable insight into the underlying mechanisms that regulate the maintenance of cellular homeostasis. Here, we will summarize the current knowledge regarding the role of mitochondria as a potential regulator of myogenesis.
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