Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury.
Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury.
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DOI：
10.4103/1673-5374.191199
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发表时间：
2016-09
影响因子：
6.1
通讯作者：
Martin JH
中科院分区：
文献类型：
--
作者：
Martin JH
As most spinal cord injuries (SCIs) are incomplete, an important target for promoting neural repair and recovery of lost motor function is to promote the connections of spared descending spinal pathways with spinal motor circuits. Among the pathways, the corticospinal tract (CST) is most associated with skilled voluntary functions in humans and many animals. CST loss, whether at its origin in the motor cortex or in the white matter tracts subcortically and in the spinal cord, leads to movement impairments and paralysis. To restore motor function after injury will require repair of the damaged CST. In this review, I discuss how knowledge of activity-dependent development of the CST—which establishes connectional specificity through axon pruning, axon outgrowth, and synaptic competition among CST terminals—informed a novel activity-based therapy for promoting sprouting of spared CST axons after injur in mature animals. This therapy, which comprises motor cortex electrical stimulation with and without concurrent trans-spinal direct current stimulation, leads to an increase in the gray matter axon length of spared CST axons in the rat spinal cord and, after a pyramidal tract lesion, restoration of skilled locomotor movements. I discuss how this approach is now being applied to a C4 contusion rat model.
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影响因子：
3.5
作者：
Carmel JB;Martin JH
通讯作者：
Martin JH
影响因子：
5.3
作者：
Brus-Ramer, Marcel;Carmel, Jason B.;Martin, John H.
通讯作者：
Martin, John H.
DOI：
10.1523/jneurosci.1435-10.2010
发表时间：
2010-08-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Carmel JB;Berrol LJ;Brus-Ramer M;Martin JH
通讯作者：
Martin JH
DOI：
10.1073/pnas.051626798
发表时间：
2001-03-13
影响因子：
11.1
作者：
Weidner, N;Ner, A;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
5.3
作者：
Salimi, I;Martin, JH
通讯作者：
Martin, JH