Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.
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DOI：
10.1016/j.chom.2021.10.003
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发表时间：
2021-11-10
影响因子：
30.3
通讯作者：
Burgers WA
中科院分区：
文献类型：
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作者：
Keeton R;Richardson SI;Moyo-Gwete T;Hermanus T;Tincho MB;Benede N;Manamela NP;Baguma R;Makhado Z;Ngomti A;Motlou T;Mennen M;Chinhoyi L;Skelem S;Maboreke H;Doolabh D;Iranzadeh A;Otter AD;Brooks T;Noursadeghi M;Moon JC;Grifoni A;Weiskopf D;Sette A;Blackburn J;Hsiao NY;Williamson C;Riou C;Goga A;Garrett N;Bekker LG;Gray G;Ntusi NAB;Moore PL;Burgers WA
约翰逊和约翰逊Ad26.COV2.S单剂疫苗代表了资源有限国家2019冠状病毒病（COVID-19）疫苗接种的一种有吸引力的选择。我们检测了不同SARS-CoV-2变异体对Ad26.COV2.S免疫原性的影响。我们比较了SARS-CoV-2初治的参与者与感染祖先D 614 G病毒或在β病毒占主导地位的第二波感染的参与者。既往感染可显著增强尖峰结合抗体、抗体依赖性细胞毒性和针对D 614 G、β和δ的中和抗体;然而，中和交叉反应性因波而异。无论之前是否感染，接种疫苗后都会诱导稳健的CD 4和CD 8 T细胞应答。T细胞对变体的识别在很大程度上得以保留，除了Delta的CD 8识别有所减少。因此，感染后接种Ad26.COV2.S疫苗可增强对COVID-19的保护。感染变异对接种后中和宽度的影响对基于关注变异的第二代疫苗的设计具有影响。Keeton，Richardson，Moyo-Gwete，等.显示在Ad26CoV2.S疫苗接种之前SARS-CoV-2感染显著增强了交叉反应性ADCC和结合及中和抗体，并适度增强了针对所关注变体的T细胞应答。此外，感染病毒刺突序列决定了中和反应的交叉反应性，这对第二代疫苗设计具有影响。
The Johnson and Johnson Ad26.COV2.S single-dose vaccine represents an attractive option for coronavirus disease 2019 (COVID-19) vaccination in countries with limited resources. We examined the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity. We compared participants who were SARS-CoV-2 naive with those either infected with the ancestral D614G virus or infected in the second wave when Beta predominated. Prior infection significantly boosts spike-binding antibodies, antibody-dependent cellular cytotoxicity, and neutralizing antibodies against D614G, Beta, and Delta; however, neutralization cross-reactivity varied by wave. Robust CD4 and CD8 T cell responses are induced after vaccination, regardless of prior infection. T cell recognition of variants is largely preserved, apart from some reduction in CD8 recognition of Delta. Thus, Ad26.COV2.S vaccination after infection could result in enhanced protection against COVID-19. The impact of the infecting variant on neutralization breadth after vaccination has implications for the design of second-generation vaccines based on variants of concern. Keeton, Richardson, Moyo-Gwete, et al. show that SARS-CoV-2 infection prior to Ad26CoV2.S vaccination significantly boosts cross-reactive ADCC and binding and neutralizing antibodies and moderately boosts T cell responses against variants of concern. Furthermore, the infecting virus spike sequence determines the cross-reactivity of neutralizing responses, with implications for second-generation vaccine design.
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影响因子：
64.5
作者：
Liu C;Ginn HM;Dejnirattisai W;Supasa P;Wang B;Tuekprakhon A;Nutalai R;Zhou D;Mentzer AJ;Zhao Y;Duyvesteyn HME;López-Camacho C;Slon-Campos J;Walter TS;Skelly D;Johnson SA;Ritter TG;Mason C;Costa Clemens SA;Gomes Naveca F;Nascimento V;Nascimento F;Fernandes da Costa C;Resende PC;Pauvolid-Correa A;Siqueira MM;Dold C;Temperton N;Dong T;Pollard AJ;Knight JC;Crook D;Lambe T;Clutterbuck E;Bibi S;Flaxman A;Bittaye M;Belij-Rammerstorfer S;Gilbert SC;Malik T;Carroll MW;Klenerman P;Barnes E;Dunachie SJ;Baillie V;Serafin N;Ditse Z;Da Silva K;Paterson NG;Williams MA;Hall DR;Madhi S;Nunes MC;Goulder P;Fry EE;Mongkolsapaya J;Ren J;Stuart DI;Screaton GR
通讯作者：
Screaton GR
影响因子：
56.9
作者：
Hsieh, Ching-Lin;Goldsmith, Jory A.;McLellan, Jason S.
通讯作者：
McLellan, Jason S.
影响因子：
5.8
作者：
Cleemput, Sara;Dumon, Wim;de Oliveira, Tulio
通讯作者：
de Oliveira, Tulio
DOI：
10.1056/nejmoa2101544
发表时间：
2021-06-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sadoff J;Gray G;Vandebosch A;Cárdenas V;Shukarev G;Grinsztejn B;Goepfert PA;Truyers C;Fennema H;Spiessens B;Offergeld K;Scheper G;Taylor KL;Robb ML;Treanor J;Barouch DH;Stoddard J;Ryser MF;Marovich MA;Neuzil KM;Corey L;Cauwenberghs N;Tanner T;Hardt K;Ruiz-Guiñazú J;Le Gars M;Schuitemaker H;Van Hoof J;Struyf F;Douoguih M;ENSEMBLE Study Group
通讯作者：
ENSEMBLE Study Group
影响因子：
64.8
作者：
Alter G;Yu J;Liu J;Chandrashekar A;Borducchi EN;Tostanoski LH;McMahan K;Jacob-Dolan C;Martinez DR;Chang A;Anioke T;Lifton M;Nkolola J;Stephenson KE;Atyeo C;Shin S;Fields P;Kaplan I;Robins H;Amanat F;Krammer F;Baric RS;Le Gars M;Sadoff J;de Groot AM;Heerwegh D;Struyf F;Douoguih M;van Hoof J;Schuitemaker H;Barouch DH
通讯作者：
Barouch DH