Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood.
Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood.
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DOI：
10.1111/acel.12750
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发表时间：
2018-04
期刊：
影响因子：
7.8
通讯作者：
Lord JM
中科院分区：
文献类型：
--
作者：
Duggal NA;Pollock RD;Lazarus NR;Harridge S;Lord JM
人们普遍认为，衰老伴随着免疫系统的重塑，包括胸腺萎缩和衰老T细胞频率的增加，导致免疫功能受损。然而，体力活动会影响免疫力，但随着年龄的增长会急剧下降，本文不考虑这一点。我们评估了125名成年人(55-79岁)的免疫状况，他们在成年生活的大部分时间里一直保持高水平的体育活动(骑自行车)，75名年龄匹配的老年人和55名没有定期锻炼的年轻人。骑自行车者幼稚T细胞和新近胸腺移居者(RTE)的频率均高于不活跃的老年人，而RTE频率与青壮年无差异。与不太活跃的人相比，骑自行车的人血清中保护胸腺的细胞因子IL-7水平显著升高，而促进胸腺萎缩的IL-6水平则更低。骑自行车的人还表现出免疫衰老降低的额外证据，即比不活动的老年人更低的Th17极化和更高的B调节细胞频率。体力活动并不能预防免疫衰老的所有方面：CD28Ve CD57+Ve衰老的−T细胞频率在骑自行车的人和不活动的老年人之间没有差别。我们得出结论，免疫衰老的许多特征可能是由随着年龄增长而减少的体力活动所驱动的。
It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (55–79 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age‐matched older adults and 55 young adults not involved in regular exercise. The frequency of naïve T cells and recent thymic emigrants (RTE) were both higher in cyclists compared with inactive elders, and RTE frequency in cyclists was no different to young adults. Compared with their less active counterparts, the cyclists had significantly higher serum levels of the thymoprotective cytokine IL‐7 and lower IL‐6, which promotes thymic atrophy. Cyclists also showed additional evidence of reduced immunesenescence, namely lower Th17 polarization and higher B regulatory cell frequency than inactive elders. Physical activity did not protect against all aspects of immunesenescence: CD28−ve CD57+ve senescent CD8 T‐cell frequency did not differ between cyclists and inactive elders. We conclude that many features of immunesenescence may be driven by reduced physical activity with age.
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影响因子：
7.8
作者：
Duggal NA;Upton J;Phillips AC;Sapey E;Lord JM
通讯作者：
Lord JM
DOI：
10.1084/jem.20080996
发表时间：
2009-02-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Haines CJ;Giffon TD;Lu LS;Lu X;Tessier-Lavigne M;Ross DT;Lewis DB
通讯作者：
Lewis DB
影响因子：
4.6
作者：
Mitchell, W. A.;Lang, P. O.;Aspinall, R.
通讯作者：
Aspinall, R.
影响因子：
5.5
作者：
Haugen, Fred;Norheim, Frode;Drevon, Christian A.
通讯作者：
Drevon, Christian A.
DOI：
10.1186/s12979-014-0025-5
发表时间：
2014
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Duggal NA;Upton J;Phillips AC;Hampson P;Lord JM
通讯作者：
Lord JM