Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism.
Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism.
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DOI：
10.1002/dev.22006
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发表时间：
2021-01
影响因子：
2.2
通讯作者：
Kikusui T
中科院分区：
文献类型：
--
作者：
Kato R;Machida A;Nomoto K;Kang G;Hiramoto T;Tanigaki K;Mogi K;Hiroi N;Kikusui T
新生小鼠幼仔超声发声（USV）的内在序列结构和母亲的经验如何决定小鼠的母亲行为还知之甚少。我们以前的工作表明，具有Tbx 1杂合（HT）突变（自闭症谱系障碍（ASD）的遗传风险）的幼崽发出改变的呼叫序列，不会诱导C57 BL 6/J母亲的母性接近行为。在这里，我们测试了野生型和HT USV诱导的母性接近行为如何受到母亲在养育这两种基因型幼崽时的经验的影响。结果表明，野生型USV是有效地诱导母亲的接近行为时，母亲提出了野生型，但不是HT幼崽。无论母亲是否饲养HT或野生型幼崽，HT幼崽的USV都是无效的。然而，序列结构的幼犬USVs没有影响一般的，非定向的激励动机的母性行为。我们的数据显示，母亲的经验与遗传风险的ASD的幼犬改变了内在的激励价值的USV序列在母亲的方法行为。
How the intrinsic sequence structure of neonatal mouse pup ultrasonic vocalization (USV) and maternal experiences determine maternal behaviors in mice is poorly understood. Our previous work showed that pups with a Tbx1 heterozygous (HT) mutation, a genetic risk for autism spectrum disorder (ASD), emit altered call sequences that do not induce maternal approach behaviors in C57BL6/J mothers. Here, we tested how maternal approach behaviors induced by wild-type and HT USVs are influenced by the mother’s experience in raising pups of these two genotypes. The results showed that wild-type USVs were effective in inducing maternal approach behaviors when mothers raised wild-type but not HT pups. The USVs of HT pups were ineffective regardless of whether mothers raised HT or wild-type pups. However, the sequence structure of pup USVs had no effect on the general, non-directional incentive motivation of maternal behaviors. Our data show how the mother’s experience with a pup with a genetic risk for ASD alters the intrinsic incentive values of USV sequences in maternal approach behaviors.
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影响因子：
11.9
作者：
Hiroi N
通讯作者：
Hiroi N
影响因子：
3.7
作者：
Ogata T;Niihori T;Tanaka N;Kawai M;Nagashima T;Funayama R;Nakayama K;Nakashima S;Kato F;Fukami M;Aoki Y;Matsubara Y
通讯作者：
Matsubara Y
影响因子：
11
作者：
Takahashi T;Okabe S;Broin PÓ;Nishi A;Ye K;Beckert MV;Izumi T;Machida A;Kang G;Abe S;Pena JL;Golden A;Kikusui T;Hiroi N
通讯作者：
Hiroi N
影响因子：
0.9
作者：
Okabe, Shota;Nagasawa, Miho;Kikusui, Takefumi
通讯作者：
Kikusui, Takefumi
DOI：
10.1073/pnas.0600206103
发表时间：
2006-05-16
影响因子：
11.1
作者：
Paylor, Richard;Glaser, Beate;Lindsay, Elizabeth
通讯作者：
Lindsay, Elizabeth