Drug-Repositioning Approaches Based on Medical and Life Science Databases.
Drug-Repositioning Approaches Based on Medical and Life Science Databases.
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DOI：
10.3389/fphar.2021.752174
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发表时间：
2021
影响因子：
5.6
通讯作者：
Ishizawa K
中科院分区：
文献类型：
--
作者：
Zamami Y;Hamano H;Niimura T;Aizawa F;Yagi K;Goda M;Izawa-Ishizawa Y;Ishizawa K
药物重新定位是一种药物发现战略，在这种战略中，现有药物被用作不同疾病的治疗剂。由于现有药物的安全性、药代动力学和配方方面的信息已经可用，药物开发所需的成本和时间就会减少。传统的药物重新定位一直被一种方法所主导，这种方法涉及通过基础研究寻找作用于处于疾病状态的生物体的靶分子的候选药物。然而，最近，医学信息和生命科学数据库上的信息被用于转译研究，以弥合药物重新定位基础研究和临床应用之间的差距。在这里，我们回顾了一个药物重新定位的例子，其中发现了候选药物，并通过结合从各种医学和生命科学数据库检索的结果的基础研究方法确定了它们针对新的治疗靶点的作用机制。
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost and time required for drug development is reduced. Conventional drug repositioning has been dominated by a method involving the search for candidate drugs that act on the target molecules of an organism in a diseased state through basic research. However, recently, information hosted on medical information and life science databases have been used in translational research to bridge the gap between basic research in drug repositioning and clinical application. Here, we review an example of drug repositioning wherein candidate drugs were found and their mechanisms of action against a novel therapeutic target were identified via a basic research method that combines the findings retrieved from various medical and life science databases.
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影响因子：
5.6
作者：
Behl T;Kaur I;Sehgal A;Singh S;Bhatia S;Al-Harrasi A;Zengin G;Babes EE;Brisc C;Stoicescu M;Toma MM;Sava C;Bungau SG
通讯作者：
Bungau SG
影响因子：
5.6
作者：
Chong LC;Gandhi G;Lee JM;Yeo WWY;Choi SB
通讯作者：
Choi SB
DOI：
10.1073/pnas.1620433114
发表时间：
2017-01-31
影响因子：
11.1
作者：
Chamoto, Kenji;Chowdhury, Partha S.;Honjo, Tasuku
通讯作者：
Honjo, Tasuku
影响因子：
158.5
作者：
Grein, J.;Ohmagari, N.;Flanigan, T.
通讯作者：
Flanigan, T.
DOI：
10.1111/cts.13045
发表时间：
2021-09
期刊：
Clinical and translational science
影响因子：
--
作者：
Goda M;Kanda M;Yoshioka T;Yoshida A;Murai Y;Zamami Y;Aizawa F;Niimura T;Hamano H;Okada N;Yagi K;Chuma M;Izawa-Ishizawa Y;Ishizawa K
通讯作者：
Ishizawa K