Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry.
Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry.
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DOI：
10.3390/ijms22126184
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发表时间：
2021-06-08
影响因子：
5.6
通讯作者：
Bungau SG
中科院分区：
文献类型：
--
作者：
Behl T;Kaur I;Sehgal A;Singh S;Bhatia S;Al-Harrasi A;Zengin G;Babes EE;Brisc C;Stoicescu M;Toma MM;Sava C;Bungau SG
随着先进技术的发展，生物信息学是前卫领域之一，通过对医疗保健的基础设施维度进行建模，并将计算工具集成到药物创新中，促进疾病的预防、检测/更准确的诊断和治疗，同时节省时间和金钱，从而在制药-医疗领域取得了惊人的进步。通过关联，生物信息学和药物警戒促进了对药物副作用的样本分析和解释，并将重点放在药物发现和开发(DDD)上，其中系统生物学、个性化方法和药物重新定位与转化医学一起被考虑。生物信息学在DDD、蛋白质组学、遗传学、建模、miRNA的发现和评估以及临床基因组测序中的作用已得到强调。作者整理了来自最著名的在线数据库和出版商的重要数据，也缩小了多样化的应用范围，以针对四个主要领域(四重领域)：DDD、抗微生物研究、基因组测序和miRNA研究及其在当前大流行背景下的管理意义。我们的分析旨在通过对与关键部门公布的数据相关的信息进行分层来提供该领域的最佳数据，并吸引对生物信息学感兴趣的研究人员的注意，生物信息学是一个通过引入开发技术和多个数据库平台成功地推进医疗保健范式的领域，如手稿中所述。
With advanced technology and its development, bioinformatics is one of the avant-garde fields that has managed to make amazing progress in the pharmaceutical–medical field by modeling the infrastructural dimensions of healthcare and integrating computing tools in drug innovation, facilitating prevention, detection/more accurate diagnosis, and treatment of disorders, while saving time and money. By association, bioinformatics and pharmacovigilance promoted both sample analyzes and interpretation of drug side effects, also focusing on drug discovery and development (DDD), in which systems biology, a personalized approach, and drug repositioning were considered together with translational medicine. The role of bioinformatics has been highlighted in DDD, proteomics, genetics, modeling, miRNA discovery and assessment, and clinical genome sequencing. The authors have collated significant data from the most known online databases and publishers, also narrowing the diversified applications, in order to target four major areas (tetrad): DDD, anti-microbial research, genomic sequencing, and miRNA research and its significance in the management of current pandemic context. Our analysis aims to provide optimal data in the field by stratification of the information related to the published data in key sectors and to capture the attention of researchers interested in bioinformatics, a field that has succeeded in advancing the healthcare paradigm by introducing developing techniques and multiple database platforms, addressed in the manuscript.
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影响因子：
4.6
作者：
Bhomia M;Balakathiresan NS;Wang KK;Papa L;Maheshwari RK
通讯作者：
Maheshwari RK
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
11
作者：
Bowman, Jeff S.;Rasmussen, Simon;Sicheritz-Ponten, Thomas
通讯作者：
Sicheritz-Ponten, Thomas
影响因子：
14.9
作者：
Bairoch, Amos;Bougueleret, Lydie;Zhang, Jian
通讯作者：
Zhang, Jian
影响因子：
3
作者：
Jacobsen A;Krogh A;Kauppinen S;Lindow M
通讯作者：
Lindow M