Investigating Language and Domain-General Processing in Neurotypicals and Individuals With Aphasia - A Functional Near-Infrared Spectroscopy Pilot Study.
Investigating Language and Domain-General Processing in Neurotypicals and Individuals With Aphasia - A Functional Near-Infrared Spectroscopy Pilot Study.
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DOI：
10.3389/fnhum.2021.728151
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发表时间：
2021
影响因子：
2.9
通讯作者：
Kiran S
中科院分区：
文献类型：
--
作者：
Gilmore N;Yücel MA;Li X;Boas DA;Kiran S
与中风后语言恢复相关的大脑重组模式长期以来一直存在争议。研究中风后失语症的自发性和治疗诱导的语言恢复机制需要一种基于网络的方法，因为有可能招募病灶周围的左半球语言区域、同源的右半球语言区域和/或备用的双侧一般区域。功能近红外光谱（fNIRS）的最新硬件，软件和方法的进步使其非常适合研究这个问题。fNIRS具有成本效益，禁忌症最少，使其成为监测治疗相关脑激活随时间变化的可靠选择。通过fNIRS在语言和领域一般认知过程中建立神经典型成年人的清晰激活模式是重要的第一步。一些fNIRS研究调查了健康成年人的关键语言过程，但在方法学限制的背景下解释这些发现具有挑战性。这项初步研究使用fNIRS来捕获神经型和失语症患者在语言和一般领域处理过程中的大脑激活。这些发现将作为未来解释中风后失语症患者脑激活模式治疗相关变化的参考。24名年轻健康对照者、17名老年健康对照者和6名患有左半球中风诱发失语症的人完成了两项语言任务（即，语义特征，图片命名）和一个领域通用认知任务（即，在fNIRS期间两次。探头覆盖双侧额叶、顶叶和颞叶，并包括用于头皮信号干扰回归的短间隔探测器。年轻和年长的健康对照在语义特征处理过程中激活了核心语言区域（例如，左额下回盖部）和词汇提取（例如，左额下回三角部）和一般域区域（例如，双侧额中回）。与中风后语言恢复的理论相一致，失语症患者激活了传统网络之外的区域：在语义特征判断过程中激活了左侧上级额上回和左侧缘上回;在图片命名过程中激活了左侧上级额上回和右侧中央前回;在算术处理过程中激活了左侧额下回的盖部。中风组的初步研究结果强调了使用fNIRS研究失语症的语言和领域一般处理的实用性。
Brain reorganization patterns associated with language recovery after stroke have long been debated. Studying mechanisms of spontaneous and treatment-induced language recovery in post-stroke aphasia requires a network-based approach given the potential for recruitment of perilesional left hemisphere language regions, homologous right hemisphere language regions, and/or spared bilateral domain-general regions. Recent hardware, software, and methodological advances in functional near-infrared spectroscopy (fNIRS) make it well-suited to examine this question. fNIRS is cost-effective with minimal contraindications, making it a robust option to monitor treatment-related brain activation changes over time. Establishing clear activation patterns in neurotypical adults during language and domain-general cognitive processes via fNIRS is an important first step. Some fNIRS studies have investigated key language processes in healthy adults, yet findings are challenging to interpret in the context of methodological limitations. This pilot study used fNIRS to capture brain activation during language and domain-general processing in neurotypicals and individuals with aphasia. These findings will serve as a reference when interpreting treatment-related changes in brain activation patterns in post-stroke aphasia in the future. Twenty-four young healthy controls, seventeen older healthy controls, and six individuals with left hemisphere stroke-induced aphasia completed two language tasks (i.e., semantic feature, picture naming) and one domain-general cognitive task (i.e., arithmetic) twice during fNIRS. The probe covered bilateral frontal, parietal, and temporal lobes and included short-separation detectors for scalp signal nuisance regression. Younger and older healthy controls activated core language regions during semantic feature processing (e.g., left inferior frontal gyrus pars opercularis) and lexical retrieval (e.g., left inferior frontal gyrus pars triangularis) and domain-general regions (e.g., bilateral middle frontal gyri) during hard versus easy arithmetic as expected. Consistent with theories of post-stroke language recovery, individuals with aphasia activated areas outside the traditional networks: left superior frontal gyrus and left supramarginal gyrus during semantic feature judgment; left superior frontal gyrus and right precentral gyrus during picture naming; and left inferior frontal gyrus pars opercularis during arithmetic processing. The preliminary findings in the stroke group highlight the utility of using fNIRS to study language and domain-general processing in aphasia.
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影响因子：
4.2
作者：
Descorbeth O;Zhang X;Noah JA;Hirsch J
通讯作者：
Hirsch J
影响因子：
5.7
作者：
Bonakdarpour, B.;Parrish, T. B.;Thompson, C. K.
通讯作者：
Thompson, C. K.
DOI：
10.1073/pnas.1112937108
发表时间：
2011-09-27
影响因子：
11.1
作者：
Fedorenko, Evelina;Behr, Michael K.;Kanwisher, Nancy
通讯作者：
Kanwisher, Nancy
影响因子：
2.5
作者：
Dieler, A. C.;Tupak, S. V.;Fallgatter, A. J.
通讯作者：
Fallgatter, A. J.
影响因子：
3.1
作者：
Artemenko, Christina;Soltanlou, Mojtaba;Nuerk, Hans-Christoph
通讯作者：
Nuerk, Hans-Christoph