Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development.
Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development.
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DOI：
10.1038/s41598-018-33767-3
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发表时间：
2018-10-18
影响因子：
4.6
通讯作者：
Campino S
中科院分区：
文献类型：
--
作者：
Benavente ED;Oresegun DR;de Sessions PF;Walker EM;Roper C;Dombrowski JG;de Souza RM;Marinho CRF;Sutherland CJ;Hibberd ML;Mohareb F;Baker DA;Clark TG;Campino S
孕期疟疾感染是由于恶性疟原虫在胎盘中隔离而引起的，导致婴儿死亡率和孕产妇发病率较高。寄生虫-胎盘黏附机制是由VAR2CSA蛋白介导的，VAR2CSA蛋白是自然发生免疫的靶标。目前，疫苗的开发是基于其ID1-DBL2Xb结构域，但对编码var2csa基因的全球遗传多样性知之甚少，这可能会影响疫苗的效果。在对23个国家和地区的2,000个 恶性疟原虫田间分离株的var2csa基因的综合分析中，我们发现var2csa在高发人群中复制(>；25%)，非洲和大洋洲人群的多样性比其他地区高得多，而且大量的插入/缺失导致了对该基因座多样性的低估。此外，与不良出生结局相关的ID1-DBL2Xb单倍型在全球范围内都存在，并且存在非洲特有的单倍型，这些单倍型应该被纳入疫苗设计。
Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite-placenta adherence mechanism is mediated by the VAR2CSA protein, a target for natural occurring immunity. Currently, vaccine development is based on its ID1-DBL2Xb domain however little is known about the global genetic diversity of the encoding var2csa gene, which could influence vaccine efficacy. In a comprehensive analysis of the var2csa gene in >2,000 P. falciparum field isolates across 23 countries, we found that var2csa is duplicated in high prevalence (>25%), African and Oceanian populations harbour a much higher diversity than other regions, and that insertions/deletions are abundant leading to an underestimation of the diversity of the locus. Further, ID1-DBL2Xb haplotypes associated with adverse birth outcomes are present globally, and African-specific haplotypes exist, which should be incorporated into vaccine design.
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影响因子：
3
作者：
Ravenhall M;Benavente ED;Mipando M;Jensen AT;Sutherland CJ;Roper C;Sepúlveda N;Kwiatkowski DP;Montgomery J;Phiri KS;Terlouw A;Craig A;Campino S;Ocholla H;Clark TG
通讯作者：
Clark TG
DOI：
10.1093/bioinformatics/btr670
发表时间：
2012-02-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Boeva V;Popova T;Bleakley K;Chiche P;Cappo J;Schleiermacher G;Janoueix-Lerosey I;Delattre O;Barillot E
通讯作者：
Barillot E
影响因子：
12.3
作者：
Brolin KJ;Ribacke U;Nilsson S;Ankarklev J;Moll K;Wahlgren M;Chen Q
通讯作者：
Chen Q
影响因子：
4.6
作者：
Patel JC;Hathaway NJ;Parobek CM;Thwai KL;Madanitsa M;Khairallah C;Kalilani-Phiri L;Mwapasa V;Massougbodji A;Fievet N;Bailey JA;Ter Kuile FO;Deloron P;Engel SM;Taylor SM;Juliano JJ;Tuikue Ndam N;Meshnick SR
通讯作者：
Meshnick SR
DOI：
10.1093/bioinformatics/bts378
发表时间：
2012-09-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Rausch T;Zichner T;Schlattl A;Stütz AM;Benes V;Korbel JO
通讯作者：
Korbel JO