Molecular mechanisms underlying nutrient detection by incretin-secreting cells.
Molecular mechanisms underlying nutrient detection by incretin-secreting cells.
复制标题
DOI：
10.1016/j.idairyj.2009.11.014
复制
发表时间：
2010-04
影响因子：
3.1
通讯作者：
Reimann F
中科院分区：
文献类型：
--
作者：
Reimann F
激素葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）分别在餐后从肠K细胞和L细胞分泌。作为肠促胰岛素，这些激素刺激胰腺β细胞分泌胰岛素，并独立地参与控制食物摄入和脂质代谢。虽然产生GIP和GLP-1的肠内分泌细胞因此是治疗糖尿病和肥胖的有吸引力的靶点，但我们对其生理学的理解相当有限。已经使用器官灌注技术、原代上皮培养物和细胞系模型研究了用于感测碳水化合物、脂肪和蛋白质到达肠腔的机制。最近开发的小鼠与荧光标记的GIP或GLP-1表达细胞，现在能够使用单细胞技术来研究刺激分泌偶联机制。这篇评论将集中在目前的知识的分子机制的基础上的K-和L-细胞内的营养感应。
The hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are secreted postprandially from intestinal K- and L-cells, respectively. As incretins, these hormones stimulate insulin secretion from the pancreatic β-cell, and have independently been implicated in the control of food intake and lipid metabolism. Whilst the enteroendocrine cells producing GIP and GLP-1 are therefore attractive targets for the treatment of diabetes and obesity, our understanding of their physiology is fairly limited. The mechanisms employed to sense the arrival of carbohydrate, fat and protein in the gut lumen have been investigated using organ perfusion techniques, primary epithelial cultures and cell line models. The recent development of mice with fluorescently labeled GIP or GLP-1-expressing cells is now enabling the use of single cell techniques to investigate stimulus-secretion coupling mechanisms. This review will focus on the current knowledge of the molecular machinery underlying nutrient sensing within K- and L-cells.
登录
查看更多内容
影响因子：
16.2
作者：
Brown RJ;Walter M;Rother KI
通讯作者：
Rother KI
影响因子：
7.7
作者：
Chia, Chee W.;Carlson, Olga D.;Egan, Josephine M.
通讯作者：
Egan, Josephine M.
影响因子：
4.8
作者：
Chu, Zhi-Liang;Carroll, Chris;Leonard, James
通讯作者：
Leonard, James
影响因子：
4.8
作者：
Althage, Matthew C.;Ford, Eric L.;Wice, Burton M.
通讯作者：
Wice, Burton M.
影响因子：
8.2
作者：
EBERT, R;CREUTZFELDT, W;ARNOLD, R
通讯作者：
ARNOLD, R