TBC1D3 family is a prognostic biomarker and correlates with immune infiltration in kidney renal clear cell carcinoma.
TBC1D3 family is a prognostic biomarker and correlates with immune infiltration in kidney renal clear cell carcinoma.
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TBC1D3 家族是一种预后生物标志物，与肾透明细胞癌的免疫浸润相关
DOI：
10.1016/j.omto.2021.06.014
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发表时间：
2021-09-24
期刊：
影响因子：
--
通讯作者：
Hua H
中科院分区：
文献类型：
--
作者：
Wang B;Chen D;Hua H
TBC1D3家族在许多癌症中过表达，包括与肿瘤浸润淋巴细胞相关的肾透明细胞癌（KIRC）。然而，TBC1D3家族和肿瘤浸润淋巴细胞在KIRC中的表达和预后仍不清楚。在本研究中，我们系统地探索和验证了TBC1D3家族的表达和预后价值在KIRC使用多个公共数据库。此外，研究了TBC1D3家族成员的功能以及TBC1D3家族表达与KIRC免疫浸润水平之间的相关性。我们发现TBC1D3家族成员很少突变（少于5个频率）。TBC1D3家族在KIRC中过表达，TBC1D3家族成员的高表达与不良预后相关。此外，TBC1D3D可能正性调节细胞增殖，TBC1D3过表达促进肾透明细胞癌的体外增殖。在免疫浸润水平方面，TBC1D3家族表达与CD4+ T细胞浸润水平呈正相关。这些结果表明，TBC1D3家族的表达与预后和免疫浸润水平相关。因此，TBC1D3家族可用作KIRC的生物标志物和用于确定KIRC中的预后和免疫浸润水平的预后生物标志物。TBC1D3家族可用作肾透明细胞癌（KIRC）的生物标志物和预后生物标志物。此外，TBC1D3促进KIRC中的细胞增殖，并与免疫浸润水平和T细胞耗竭相关。
The TBC1D3 family is overexpressed in many cancers, including kidney renal clear cell carcinoma (KIRC), which is associated with tumor-infiltrating lymphocytes. However, the expression and prognosis of TBC1D3 family and tumor-infiltrating lymphocytes in KIRC remain unknown. In the present study, we systematically explored and validated the expression and prognostic value of TBC1D3 family expression in KIRC using multiple public databases. In addition, the function of the TBC1D3 family members and the correlations between TBC1D3 family expression and KIRC immune infiltration levels were investigated. We found that TBC1D3 family members were rarely mutated (less than 5 frequencies). TBC1D3 family was overexpressed in KIRC; high expression of the TBC1D3 family members was correlated with poor prognosis. In addition, TBC1D3D may positively regulate proliferation, and overexpression of TBC1D3 promoted clear cell renal cell carcinoma proliferation in vitro. In terms of immune infiltrating levels, TBC1D3 family expression was positively associated with CD4+ T cells infiltrating levels. These findings suggest that the TBC1D3 family expression is correlated with prognosis and immune infiltrating levels. Therefore, the TBC1D3 family can be used as a biomarker for KIRC and a prognostic biomarker for determining the prognosis and immune infiltration levels in KIRC. The TBC1D3 family can be used as a biomarker for kidney renal clear cell carcinoma (KIRC) and a prognostic biomarker. In addition, TBC1D3 promotes the cell proliferation and correlates with immune infiltration levels and T cell exhaustion in KIRC.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
12.3
作者：
Şenbabaoğlu Y;Gejman RS;Winer AG;Liu M;Van Allen EM;de Velasco G;Miao D;Ostrovnaya I;Drill E;Luna A;Weinhold N;Lee W;Manley BJ;Khalil DN;Kaffenberger SD;Chen Y;Danilova L;Voss MH;Coleman JA;Russo P;Reuter VE;Chan TA;Cheng EH;Scheinberg DA;Li MO;Choueiri TK;Hsieh JJ;Sander C;Hakimi AA
通讯作者：
Hakimi AA
影响因子：
4.6
作者：
Nagy Á;Lánczky A;Menyhárt O;Győrffy B
通讯作者：
Győrffy B
DOI：
10.1084/jem.178.3.1121
发表时间：
1993-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Maïza H;Leca G;Mansur IG;Schiavon V;Boumsell L;Bensussan A
通讯作者：
Bensussan A