The immunoglobulins of cartilaginous fishes.

The immunoglobulins of cartilaginous fishes.
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软骨鱼类的免疫球蛋白。

DOI:
10.1016/j.dci.2020.103873
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发表时间:
2021-03
影响因子:
2.9
通讯作者:
Dooley H
Dooley H
中科院分区:
生物学3区
文献类型:
--
作者:
Matz H;Munir D;Logue J;Dooley H

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软骨鱼类,包括嵌合体、鲨鱼、鳐鱼和鳐鱼,大约与其他有颌脊椎动物一起从共同祖先中分离出来。四亿五千万年前。作为现存最古老的具有基于免疫球蛋白(Ig)的适应性免疫系统的分类类群,对这一类群的研究让我们了解了适应性免疫的进化,以及Ig的保守性和分类特异性特征。从大量基因组和转录组数据集分析序列取得了重大进展。这些发现得到了其他功能研究的支持,这些研究表征了鲨鱼及其亲属的Igs和体液反应。本文将总结我们在软骨鱼类中这些Ig同型的基因组组织、蛋白质结构和体内功能方面所了解的情况,并强调我们仍然缺乏知识的领域。
Cartilaginous fishes, comprising the chimeras, sharks, skates, and rays, split from the common ancestor with other jawed vertebrates approx. 450 million years ago. Being the oldest extant taxonomic group to possess an immunoglobulin (Ig)-based adaptive immune system, examination of this group has taught us much about the evolution of adaptive immunity, as well as the conserved and taxon-specific characteristics of Igs. Significant progress has been made analyzing sequences from numerous genomic and transcriptomic data sets. These findings have been supported by additional functional studies characterizing the Igs and humoral response of sharks and their relatives. This review will summarize what we have learned about the genomic organization, protein structure, and in vivo function of these Ig isotypes in cartilaginous fishes and highlight the areas where our knowledge is still lacking.
DOI: 10.1007/s002510050463
发表时间: 1999-01-01
期刊: IMMUNOGENETICS
影响因子: 3.2
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