Use of fourth-generation rapid combined antigen and antibody diagnostic tests for the detection of acute HIV infection in a community centre for men who have sex with men, between 2016 and 2019.
Use of fourth-generation rapid combined antigen and antibody diagnostic tests for the detection of acute HIV infection in a community centre for men who have sex with men, between 2016 and 2019.
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在2016年至2019年之间，使用第四代快速抗原和抗体诊断测试来检测与男性发生性关系的社区中心。
DOI：
10.1371/journal.pone.0255065
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
BCN Checkpoint Working Group
中科院分区：
文献类型：
--
作者：
Saz J;Dalmau-Bueno A;Meulbroek M;Pujol F;Coll J;Herraiz-Tomey Á;Pérez F;Marazzi G;Taboada H;Culqui DR;Caylà JA;BCN Checkpoint Working Group
评估第四代快速诊断测试在识别人类免疫缺陷病毒（HIV）急性感染中的应用。BCN检查站促进男男性行为者（MSM）的性健康，重点是早期诊断艾滋病毒，及时启动联合抗逆转录病毒治疗（cART），并建议对那些检测阴性的人定期重复检测。该横断面研究包括2016年3月25日至2019年3月24日期间在中心获得的所有检查结果。Alere™ HIV Combo（现更名为Determine™ HIV Ultra，来自Abbott）用于检测HIV-1/HIV-2的p24抗原（p24 Ag）和/或免疫球蛋白M（IgM）和G（IgG）抗体（HIV Ab）。对快速检测结果阳性的患者进行快速聚合酶链反应（PCR）确证检测和免疫印迹（WB）检测。确诊的艾滋病毒病例被及时转介到艾滋病毒部门接受护理和cART处方。在研究期间，共有12，961名客户参加了BCN检查站，并进行了27，298次快速检测。发现450次检测呈反应性，其中430次确认为艾滋病毒阳性，患病率为3.32%。4例确诊病例（0.93%）被检测为“仅p24 Ag”，9例（2.09%）被检测为“p24和HIV Ab”，417例（96.98%）被检测为“仅HIV Ab”。“仅p24 Ag”组的病毒载量比其他组高1-log，并在下一个工作日开始治疗。总体而言，有20个假阳性结果（分别占总检测和反应性检测的0.07%和4.44%），其中10个为“仅p24 Ag”阳性，10个为“仅HIV Ab”阳性。4例急性HIV感染（AHI），病毒载量非常高，已被检测到“仅p24 Ag”，而HIV抗体仍然缺乏。转诊到艾滋病毒股并在下一个工作日开始cART有助于改善人们的健康，减少艾滋病毒传播链。
To assess the use of fourth-generation rapid diagnostic tests in identifying acute infection of Human Immunodeficiency Virus (HIV). BCN Checkpoint promotes sexual health among men who have sex with men (MSM), with a focus on diagnosing HIV early, initiating combined antiretroviral treatment (cART) promptly, and recommending regular repeat testing for those who have tested negative. This cross-sectional study included all test results obtained at the centre between 25 March 2016 and 24 March 2019. The Alere™ HIV Combo (now rebranded to Determine™ HIV Ultra, from Abbott) was used to detect p24 antigen (p24 Ag) and/or immunoglobulin M (IgM) and G (IgG) antibodies to HIV-1/HIV-2 (HIV Ab). Rapid polymerase chain reaction (PCR) confirmatory testing and Western blot (WB) were performed for clients with a positive rapid test result. Confirmed HIV cases were promptly referred to the HIV unit for care and cART prescription. A total of 12,961 clients attended BCN Checkpoint during the study and 27,298 rapid tests were performed. 450 tests were found to be reactive, of which 430 confirmed as HIV-positive, representing a prevalence of 3.32%. Four confirmed cases (0.93%) were detected as “p24 Ag only”, nine (2.09%) as “both p24 and HIV Ab” and 417 (96.98%) as “HIV Ab only”. The “p24 Ag only” group had a 1-log higher viral load than the other groups and initiated treatment on the following working day. Overall, there were 20 false-positive results (0.07% and 4.44% of total and reactive tests, respectively), of which 10 positive for “p24 Ag only” and 10 for “HIV Ab only”. Four Acute HIV Infections (AHI), with very high viral loads, have been detected with the “p24 Ag only” while the HIV Ab were still absent. Referral to the HIV unit and initiation of cART on the following working day contributed to improving persons’ health and to reduce HIV transmission chain.
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DOI：
10.1097/qad.0b013e328355713d
发表时间：
2012-11-28
期刊：
AIDS (London, England)
影响因子：
--
作者：
Muessig KE;Smith MK;Powers KA;Lo YR;Burns DN;Grulich AE;Phillips AN;Cohen MS
通讯作者：
Cohen MS
影响因子：
3.3
作者：
Holtgrave, David R.
通讯作者：
Holtgrave, David R.
影响因子：
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作者：
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通讯作者：
Partners in Prevention HSV/HIV Transmission Study Team
影响因子：
6.4
作者：
Hollingsworth, T. Deirdre;Anderson, Roy M.;Fraser, Christophe
通讯作者：
Fraser, Christophe
影响因子：
168.9
作者：
Granich, Reuben M.;Gilks, Charles F.;Williams, Brian G.
通讯作者：
Williams, Brian G.