Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions.
Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions.
复制标题
N6-甲基腺苷修饰与环状 RNA 之间的串扰：当前理解和未来方向
DOI：
10.1186/s12943-021-01415-6
复制
发表时间：
2021-09-24
期刊：
影响因子：
37.3
通讯作者：
Shi Y
中科院分区：
文献类型：
--
作者：
Wang X;Ma R;Zhang X;Cui L;Ding Y;Shi W;Guo C;Shi Y
N6-甲基腺苷(M6A)是真核生物RNA中普遍存在的一种内部修饰，受“编写器”、“擦除器”和“阅读器”的调控。M6A已被证明在调节RNA的成熟、定位、翻译和代谢中发挥关键的分子功能，从而在细胞、发育和疾病过程中发挥重要作用。环状RNA(CircRNAs)是一类通过后向剪接产生的具有共价闭合单链结构的非编码RNA。CircRNAs还通过独特的机制参与生理和病理过程。尽管m6A和CircRNAs是在几年前发现的，但由于近年来分子生物学技术的进步，它们吸引了越来越多的研究兴趣。最近，一些学者对M6A和CircRNA之间的串扰进行了研究。在这篇综述中，我们提供了对m6A和CircRNAs的现有知识的概述，并在现有研究的基础上总结了这些分子之间的串扰。此外，我们还对未来的研究视角提出了一些建议。
N6-methyladenosine (m6A) is a prevalent internal modification in eukaryotic RNAs regulated by the so-called “writers”, “erasers”, and “readers”. m6A has been demonstrated to exert critical molecular functions in modulating RNA maturation, localization, translation and metabolism, thus playing an essential role in cellular, developmental, and disease processes. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed single-stranded structures generated by back-splicing. CircRNAs also participate in physiological and pathological processes through unique mechanisms. Despite their discovery several years ago, m6A and circRNAs has drawn increased research interest due to advances in molecular biology techniques these years. Recently, several scholars have investigated the crosstalk between m6A and circRNAs. In this review, we provide an overview of the current knowledge of m6A and circRNAs, as well as summarize the crosstalk between these molecules based on existing research. In addition, we present some suggestions for future research perspectives.
登录
查看更多内容
影响因子：
28.2
作者：
Dixit D;Prager BC;Gimple RC;Poh HX;Wang Y;Wu Q;Qiu Z;Kidwell RL;Kim LJY;Xie Q;Vitting-Seerup K;Bhargava S;Dong Z;Jiang L;Zhu Z;Hamerlik P;Jaffrey SR;Zhao JC;Wang X;Rich JN
通讯作者：
Rich JN
影响因子：
16
作者：
Chen, Y. Grace;Chen, Robert;Chang, Howard Y.
通讯作者：
Chang, Howard Y.
影响因子：
18
作者：
Conn, Vanessa M.;Hugouvieux, Veronique;Conn, Simon J.
通讯作者：
Conn, Simon J.
影响因子：
11.4
作者：
Hansen, Thomas B.;Wiklund, Erik D.;Kjems, Jorgen
通讯作者：
Kjems, Jorgen
影响因子：
16.6
作者：
Hwang SY;Jung H;Mun S;Lee S;Park K;Baek SC;Moon HC;Kim H;Kim B;Choi Y;Go YH;Tang W;Choi J;Choi JK;Cha HJ;Park HY;Liang P;Kim VN;Han K;Ahn K
通讯作者：
Ahn K