hnRNP A1: the Swiss army knife of gene expression.
hnRNP A1: the Swiss army knife of gene expression.
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DOI：
10.3390/ijms140918999
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发表时间：
2013-09-16
影响因子：
5.6
通讯作者：
Caputi M
中科院分区：
文献类型：
--
作者：
Jean-Philippe J;Paz S;Caputi M
真核细胞表达多种RNA结合蛋白（rbp），对靶RNA具有不同的亲和力和特异性。这些蛋白几乎在RNA的生物发生、表达和功能的各个方面起着至关重要的作用。异质核核糖核蛋白（hnRNPs）是一个复杂而多样的RNA结合蛋白家族。hnRNPs在将异质核rna加工成成熟信使rna的过程中显示出多种功能。hnRNP A1是该蛋白家族中最丰富且普遍表达的成员之一。hnRNP A1通过调控新生RNA转录物加工的主要步骤，在基因表达中发挥多种作用。转录、剪接、稳定性、核孔输出以及细胞和病毒转录物的翻译都是由该蛋白调节的机制。hnRNP A1发挥的多种功能不仅限于mRNA的生物发生，还延伸到microrna的加工、端粒维持和转录因子活性的调节。基因组学方法最近揭示了hnRNP A1在生物体发育和分化中的作用程度。本文综述了该蛋白的最新研究进展，并介绍了其在细胞和病毒基因表达中的功能及其在人类病理中的作用。
Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse affinities and specificities towards target RNAs. These proteins play a crucial role in almost every aspect of RNA biogenesis, expression and function. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a complex and diverse family of RNA binding proteins. hnRNPs display multiple functions in the processing of heterogeneous nuclear RNAs into mature messenger RNAs. hnRNP A1 is one of the most abundant and ubiquitously expressed members of this protein family. hnRNP A1 plays multiple roles in gene expression by regulating major steps in the processing of nascent RNA transcripts. The transcription, splicing, stability, export through nuclear pores and translation of cellular and viral transcripts are all mechanisms modulated by this protein. The diverse functions played by hnRNP A1 are not limited to mRNA biogenesis, but extend to the processing of microRNAs, telomere maintenance and the regulation of transcription factor activity. Genomic approaches have recently uncovered the extent of hnRNP A1 roles in the development and differentiation of living organisms. The aim of this review is to highlight recent developments in the study of this protein and to describe its functions in cellular and viral gene expression and its role in human pathologies.
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