The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching.
The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching.
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DOI：
10.1186/s12915-021-01139-5
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发表时间：
2021-10-01
期刊：
影响因子：
5.4
通讯作者：
Pain A
中科院分区：
文献类型：
--
作者：
Mourier T;de Alvarenga DAM;Kaushik A;de Pina-Costa A;Douvropoulou O;Guan Q;Guzmán-Vega FJ;Forrester S;de Abreu FVS;Júnior CB;de Souza Junior JC;Moreira SB;Hirano ZMB;Pissinatti A;Ferreira-da-Cruz MF;de Oliveira RL;Arold ST;Jeffares DC;Brasil P;de Brito CFA;Culleton R;Daniel-Ribeiro CT;Pain A
疟原虫是一种非人灵长类动物（NHP）的疟疾寄生虫，最近在巴西被证明会引起人类的人畜共患感染。我们对P. simium基因组进行了测序，以研究其进化历史，并确定可能构成这种寄生虫在宿主物种之间转换能力的任何遗传适应。基于来自人类和NHP的P. simium的全基因组序列的系统发育分析揭示，P. simium在南美洲间日疟原虫的更广泛多样性中是单系的，这表明P. simium首先感染NHP是由于来自人类的间日疟原虫的宿主转换。西蒙青霉分离株与墨西哥间日青霉分离株的关系最密切。对红细胞侵袭基因的分析揭示了间日疟原虫和P. simium之间的差异，包括P. simium的Duffy结合蛋白1（DBP 1）和网织红细胞结合蛋白2a基因的大缺失。对从NHP和人类分离的P. simium的分析显示，在所有人源分离株中存在的DBP 1中缺失38个氨基酸，而NHP分离株是多等位基因的。对P. simium基因组的分析证实了P. simium和P. vivax之间的亲缘关系，并表明P. simium最近起源于美国。在检测的所有人源分离株中均存在DBP 1缺失，这表明这种缺失与P. simium中的其他遗传变化相结合，可能有助于人类红细胞的侵入，并可能至少部分解释最近人畜共患病感染的基础。在线版本包含补充材料，可通过10.1186/s12915-021-01139-5获得。
Plasmodium simium, a malaria parasite of non-human primates (NHP), was recently shown to cause zoonotic infections in humans in Brazil. We sequenced the P. simium genome to investigate its evolutionary history and to identify any genetic adaptions that may underlie the ability of this parasite to switch between host species. Phylogenetic analyses based on whole genome sequences of P. simium from humans and NHPs reveals that P. simium is monophyletic within the broader diversity of South American Plasmodium vivax, suggesting P. simium first infected NHPs as a result of a host switch of P. vivax from humans. The P. simium isolates show the closest relationship to Mexican P. vivax isolates. Analysis of erythrocyte invasion genes reveals differences between P. vivax and P. simium, including large deletions in the Duffy-binding protein 1 (DBP1) and reticulocyte-binding protein 2a genes of P. simium. Analysis of P. simium isolated from NHPs and humans revealed a deletion of 38 amino acids in DBP1 present in all human-derived isolates, whereas NHP isolates were multi-allelic. Analysis of the P. simium genome confirmed a close phylogenetic relationship between P. simium and P. vivax, and suggests a very recent American origin for P. simium. The presence of the DBP1 deletion in all human-derived isolates tested suggests that this deletion, in combination with other genetic changes in P. simium, may facilitate the invasion of human red blood cells and may explain, at least in part, the basis of the recent zoonotic infections. The online version contains supplementary material available at 10.1186/s12915-021-01139-5.
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影响因子：
6.5
作者：
Anisimova M;Gil M;Dufayard JF;Dessimoz C;Gascuel O
通讯作者：
Gascuel O
影响因子：
64.8
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
通讯作者：
Fraser-Liggett, Claire M.
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
DOI：
10.1590/0074-0276140228
发表时间：
2014-08-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Pina-Costa, Anielle de;Brasil, Patrícia;Daniel-Ribeiro, Cláudio Tadeu
通讯作者：
Daniel-Ribeiro, Cláudio Tadeu
影响因子：
--
作者：
Auburn, Sarah;Bohme, Ulrike;Otto, Thomas D
通讯作者：
Otto, Thomas D