Comparative genomics of the neglected human malaria parasite Plasmodium vivax.
Comparative genomics of the neglected human malaria parasite Plasmodium vivax.
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DOI：
10.1038/nature07327
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发表时间：
2008-10-09
期刊：
影响因子：
64.8
通讯作者：
Fraser-Liggett, Claire M.
中科院分区：
文献类型：
--
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
人类疟疾寄生虫间日疟原虫（Plasmodium vivax）占全世界每年约5.15亿疟疾病例的25-40%。虽然很少致命，寄生虫elevens严重和丧失能力的临床症状，并经常复发后几个月的原发性感染已经清除。尽管间日疟原虫作为人类主要病原体的重要性，但对它的研究很少，因为它不能在实验室中繁殖，除非在非人类灵长类动物中繁殖。我们确定了间日疟原虫的基因组序列，以揭示其独特的生物学特征，并作为推动新药和疫苗开发的手段。在这里，我们描述了间日疟原虫染色体的同线和等容线结构，并表明寄生虫类似于其他疟疾寄生虫的基因内容和代谢潜力，但具有新的基因家族和潜在的交替入侵途径以前没有认识到。间日疟原虫基因组的完成为科学界提供了宝贵的资源，可用于推进对这一被忽视物种的科学调查。
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ~515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated in the laboratory except in non-human primates. We determined the genome sequence of P. vivax in order to shed light on its distinctive biologic features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternate invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance scientific investigation into this neglected species.
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影响因子：
6.4
作者：
Imwong, Mallika;Snounou, Georges;White, Nicholas J.
通讯作者：
White, Nicholas J.
影响因子：
7
作者：
Coulson, RMR;Hall, N;Ouzounis, CA
通讯作者：
Ouzounis, CA
影响因子：
7
作者：
Gilson, Paul R.;Nebl, Thomas;Crabb, Brendan S.
通讯作者：
Crabb, Brendan S.
DOI：
10.1016/s0169-4758(00)01676-8
发表时间：
2000-07-01
期刊：
PARASITOLOGY TODAY
影响因子：
--
作者：
Ferdig, MT;Su, XZ
通讯作者：
Su, XZ
影响因子：
15.8
作者：
Carraz, Maeelle;Jossang, Akino;Mazier, Dominique
通讯作者：
Mazier, Dominique