Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles.
Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles.
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DOI：
10.1371/journal.pone.0264171
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Naito H
中科院分区：
文献类型：
--
作者：
Chang SW;Yoshihara T;Tsuzuki T;Natsume T;Kakigi R;Machida S;Naito H
我们研究了离心运动后大鼠比目鱼肌（SOL）肌肉大小的时间依赖性变化是否通过雷帕霉素（mTOR）信号通路的机制靶点进行操作。在我们的第一个实验中，我们将9周龄的雄性Wistar大鼠随机分为四组：光相（Zeitgeber时间; ZT 6）非训练对照组，暗相（ZT 18）非训练对照组，光相训练组和暗相训练组。训练动物进行90分钟的下坡跑，每3天一次，共8周。第二个实验是将9周龄的雄性Wistar大鼠分为对照组和运动组。后者在ZT 6和ZT 18进行了15 min的下坡跑。绝对（+12.8%）和相对（+9.4%）SOL肌肉重量在轻度阶段训练组中较高。p70 S6 K磷酸化比率在仅在光照下运动的大鼠（未训练的ZT 6）的SOL肌肉中高42.6%。总的来说，SOL中肌肉肥大的程度是一天中的时间依赖性的，可能通过mTOR/p70 S6 K信号传导。
We investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wistar rats randomly into four groups: light phase (zeitgeber time; ZT6) non-trained control, dark phase (ZT18) non-trained control, light phase-trained, and dark phase-trained. Trained animals performed 90 min of downhill running once every 3 d for 8 weeks. The second experiment involved dividing 9-week-old male Wistar rats to control and exercise groups. The latter were subjected to 15 min of downhill running at ZT6 and ZT18. The absolute (+12.8%) and relative (+9.4%) SOL muscle weights were higher in the light phase-trained group. p70S6K phosphorylation ratio was 42.6% higher in the SOL muscle of rats that had exercised only in light (non-trained ZT6). Collectively, the degree of muscle hypertrophy in SOL is time-of-day dependent, perhaps via the mTOR/p70S6K signaling.
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DOI：
10.1073/pnas.1014523107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Andrews, Jessica L.;Zhang, Xiping;Esser, Karyn A.
通讯作者：
Esser, Karyn A.
影响因子：
56.9
作者：
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通讯作者：
Schibler, U
影响因子：
15.9
作者：
KELLEY, DE;MOKAN, M;MANDARINO, LJ
通讯作者：
MANDARINO, LJ
影响因子：
4.2
作者：
McGhee, Nora K.;Jefferson, Leonard S.;Kimball, Scot R.
通讯作者：
Kimball, Scot R.
影响因子：
4
作者：
Ato, Satoru;Tsushima, Daisuke;Ogasawara, Riki
通讯作者：
Ogasawara, Riki