Genetic Landscape and Classification of Peripheral T Cell Lymphomas.
Genetic Landscape and Classification of Peripheral T Cell Lymphomas.
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DOI：
10.1007/s11912-017-0582-9
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发表时间：
2017-04
影响因子：
4.7
通讯作者：
Feldman AL
中科院分区：
文献类型：
--
作者：
Sandell RF;Boddicker RL;Feldman AL
外周T细胞淋巴瘤（PTCL）在临床、病理和分子水平上具有明显的异质性。这篇综述将讨论PTCL的遗传学发现，特别强调它们如何影响淋巴瘤分类。测序研究已经确定了几乎每一个PTCL亚型的复发性遗传变异。在间变性大细胞淋巴瘤中，这些研究揭示了具有预后意义的新的染色体重排和突变，并可能提出新的治疗方法。血管免疫母细胞性T细胞淋巴瘤已被发现有突变重叠的PTCL的一些情况下，没有另外指定的T滤泡辅助细胞表型。在各种亚型中，影响表观遗传调控、T细胞受体信号传导和免疫应答的基因的复发性突变和结构改变可能代表精确治疗方法的靶点。新的遗传学发现正在完善PTCL的分类，并开始在临床上用于诊断、风险分层和个体化治疗。
Peripheral T cell lymphomas (PTCLs) are markedly heterogeneous at the clinical, pathological, and molecular levels. This review will discuss genetic findings in PTCL with special emphasis on how they impact lymphoma classification. Sequencing studies have identified recurrent genetic alterations in nearly every PTCL subtype. In anaplastic large cell lymphoma, these studies have revealed novel chromosomal rearrangements and mutations that have prognostic significance and may suggest new therapeutic approaches. Angioimmunoblastic T cell lymphoma has been found to have mutations overlapping some cases of PTCL, not otherwise specified with a T follicular helper cell phenotype. Across various subtypes, recurrent mutations and structural alterations affecting genes involved in epigenetic regulation, T cell receptor signaling, and immune response may represent targets for precision therapy approaches. New genetic findings are refining the classification of PTCLs and are beginning to be used clinically for diagnosis, risk stratification, and individualized therapy.
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