Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice.
Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice.
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DOI：
10.1084/jem.20030495
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发表时间：
2003-10-20
期刊：
影响因子：
--
通讯作者：
Manser T
中科院分区：
文献类型：
--
作者：
Rahman ZS;Rao SP;Kalled SL;Manser T
调控生发中心（GC）B细胞命运的因素知之甚少。近年来的研究表明，属于肿瘤坏死因子（TNF）家族的B细胞活化因子（BAFF，也称BLyS）在促进原代B细胞存活和发育中发挥着重要作用。这种细胞因子在抗原驱动的B细胞应答中的作用已被提出，但目前这方面的数据有限。由B细胞表达的BAFF受体（BAFF-R/BR 3）在A/WySnJ小鼠中是缺陷的，其表现出与BAFF缺陷（BAFF-/-）动物相似的表型。在这里，我们表明，虽然GC反应可以有效地诱导在A/WySnJ和BAFF-/-小鼠，这些反应是不持久的。在BAFF−/−小鼠中，这种反应迅速减弱，并伴有滤泡树突状细胞发育和免疫复合物捕获的干扰。相反，A/WySnJ GC反应的分析揭示了与GC B细胞在反应的所有阶段的Ki 67核增殖抗原表达减少或不可检测相关的B细胞自主增殖缺陷。这些数据表明BAFF通路在调节GC进展中的多方面作用。
The factors regulating germinal center (GC) B cell fate are poorly understood. Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF; also called BLyS) in promoting primary B cell survival and development. A role for this cytokine in antigen-driven B cell responses has been suggested but current data in this regard are limited. A BAFF receptor expressed by B cells (BAFF-R/BR3) is defective in A/WySnJ mice which exhibit a phenotype similar to BAFF-deficient (BAFF−/−) animals. Here, we show that although GC responses can be efficiently induced in both A/WySnJ and BAFF−/− mice, these responses are not sustained. In BAFF−/− mice, this response is rapidly attenuated and accompanied by perturbed follicular dendritic cell development and immune complex trapping. In contrast, analysis of the A/WySnJ GC response revealed a B cell autonomous proliferative defect associated with reduced or undetectable Ki67 nuclear proliferation antigen expression by GC B cells at all stages of the response. These data demonstrate a multifaceted role for the BAFF pathway in regulating GC progression.
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DOI：
10.1084/jem.187.11.1735
发表时间：
1998-06-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jacobs H;Fukita Y;van der Horst GT;de Boer J;Weeda G;Essers J;de Wind N;Engelward BP;Samson L;Verbeek S;de Murcia JM;de Murcia G;te Riele H;Rajewsky K
通讯作者：
Rajewsky K
影响因子：
4.4
作者：
Fu, YX;Huang, GM;Chaplin, DD
通讯作者：
Chaplin, DD
影响因子：
64.5
作者：
BEREK, C;BERGER, A;APEL, M
通讯作者：
APEL, M
影响因子：
11.4
作者：
GU, H;FORSTER, I;RAJEWSKY, K
通讯作者：
RAJEWSKY, K
影响因子：
30.5
作者：
Claudio, E;Brown, K;Siebenlist, U
通讯作者：
Siebenlist, U