Genomic signatures of adaptive introgression from European mouflon into domestic sheep.
Genomic signatures of adaptive introgression from European mouflon into domestic sheep.
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DOI：
10.1038/s41598-017-07382-7
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发表时间：
2017-08-08
影响因子：
4.6
通讯作者：
Bruford MW
中科院分区：
文献类型：
--
作者：
Barbato M;Hailer F;Orozco-terWengel P;Kijas J;Mereu P;Cabras P;Mazza R;Pirastru M;Bruford MW
Mouflon(Ovis Aries Musimon)在新石器时代后在欧洲大陆灭绝，但自19世纪以来，地中海科西嘉岛和撒丁岛的残余种群一直被用来在欧洲各地重新引入。Mouflon与绵羊杂交的体型比Mouflon大，有可能显示出更高的雄性繁殖成功率，但人们对混合体的基因组水平或常驻Mouflon与当地绵羊品种之间渗透的适应意义知之甚少。在这里，我们分析了来自六个地理区域的92只绵羊的绵羊中密度SNP阵列基因型，以及来自16个家系绵羊品种的330个个体的数据。我们发现莫福隆羊的遗传多样性水平低于家羊，这与莫福隆过去的瓶颈一致。导入信号是双向的，影响了大多数魔龙和绵羊种群，在一个撒丁岛魔龙种群中最强。开发和使用一种新的方法来识别具有一致导入信号的染色体区域，我们推断从Mouflon到家羊的适应性导入与免疫机制有关，但不是相反的方向。此外，我们推断Soay和Sarda绵羊携带与苦味感知和/或先天免疫有关的导入Mouflon等位基因。我们的结果表明，即使在最近分化的种群中，自适应导入的潜力也是如此。
Mouflon (Ovis aries musimon) became extinct from mainland Europe after the Neolithic, but remnant populations from the Mediterranean islands of Corsica and Sardinia have been used for reintroductions across Europe since the 19th-century. Mouflon x sheep hybrids are larger-bodied than mouflon, potentially showing increased male reproductive success, but little is known about genomic levels of admixture, or about the adaptive significance of introgression between resident mouflon and local sheep breeds. Here we analysed Ovine medium-density SNP array genotypes of 92 mouflon from six geographic regions, along with data from 330 individuals of 16 domestic sheep breeds. We found lower levels of genetic diversity in mouflon than in domestic sheep, consistent with past bottlenecks in mouflon. Introgression signals were bidirectional and affected most mouflon and sheep populations, being strongest in one Sardinian mouflon population. Developing and using a novel approach to identify chromosomal regions with consistent introgression signals, we infer adaptive introgression from mouflon to domestic sheep related to immunity mechanisms, but not in the opposite direction. Further, we infer that Soay and Sarda sheep carry introgressed mouflon alleles involved in bitter taste perception and/or innate immunity. Our results illustrate the potential for adaptive introgression even among recently diverged populations.
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DOI：
10.1186/s12711-015-0139-z
发表时间：
2015-08-14
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Ciani E;Lasagna E;D'Andrea M;Alloggio I;Marroni F;Ceccobelli S;Delgado Bermejo JV;Sarti FM;Kijas J;Lenstra JA;Pilla F;International Sheep Genomics Consortium
通讯作者：
International Sheep Genomics Consortium
DOI：
10.1098/rspb.2002.1975
发表时间：
2002-05-07
影响因子：
4.7
作者：
Hiendleder, S;Kaupe, B;Janke, A
通讯作者：
Janke, A
影响因子：
1.8
作者：
Calvo, J. H.;Alvarez-Rodriguez, J.;Sanz, A.
通讯作者：
Sanz, A.
影响因子：
1.9
作者：
Guerrini, Monica;Forcina, Giovanni;Barbanera, Filippo
通讯作者：
Barbanera, Filippo
影响因子：
2.4
作者：
Hayes, B. J.;Bowman, P. J.;van der Werf, J. H. J.
通讯作者：
van der Werf, J. H. J.