Locomotor and stress responses to nicotine differ in adolescent and adult rats.
Locomotor and stress responses to nicotine differ in adolescent and adult rats.
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DOI：
10.1016/j.pbb.2010.04.010
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发表时间：
2010-07
影响因子：
3.6
通讯作者：
Leslie, Frances M.
中科院分区：
文献类型：
--
作者：
Cao, Junran;Belluzzi, James D.;Loughlin, Sandra E.;Dao, Jasmin M.;Chen, YiLing;Leslie, Frances M.
由于青春期是开始吸烟的关键时期，我们系统地比较了两性 Sprague-Dawley 大鼠在青春期早期（出生后第 28 天）、青春期中期（P38）和成年期（P90）对尼古丁的行为和内分泌反应。静脉注射盐水或尼古丁（60 µg/kg）后，评估新开放视野中的运动和中心时间 30 分钟，然后测量血浆皮质酮。观察到行为和内分泌反应方面复杂的年龄和性别差异，这取决于检查的功能终点。尽管尼古丁对所有功能指标的影响存在年龄差异，但性别差异主要限于成人压力相关的皮质酮和中心时间反应。尽管在 P28 和 P90 时检测到显着的药物作用，但在 P38 时尼古丁对任何检查的指标均没有影响。在接受生理盐水治疗的男性中，但在女性中，初始动态计数与初始垂直计数和总中心时间之间存在跨年龄的显着正相关性。尼古丁治疗增加了两性的相关性，并在初始动态计数和血浆皮质酮之间产生了显着的负相互作用。青少年对尼古丁的独特反应与该年龄段烟碱乙酰胆碱受体的不成熟功能一致。
Since adolescence is a critical period for the initiation of tobacco use, we have systematically compared behavioral and endocrine responses to nicotine in Sprague-Dawley rats of both sexes at early adolescence (postnatal day (P) 28), mid- adolescence (P38) and adulthood (P90). Locomotion and center time in a novel open field were evaluated for 30 min following intravenous injection of saline or nicotine (60 µg/kg), followed by measurement of plasma corticosterone. Complex age and sex differences in behavioral and endocrine response were observed, which were dependent on the functional endpoint examined. Whereas there were age differences in nicotine effects on all functional measures, sex differences were largely restricted to adult stress-related corticosterone and center-time responses. Although significant drug effects were detected at P28 and P90, there was no effect of nicotine at P38 on any measure examined. In saline-treated males, but not females, there were significant positive correlations across age between initial ambulatory counts and both initial vertical counts and total center time. Nicotine treatment increased correlations in both sexes, and yielded a significant negative interaction between initial ambulatory counts and plasma corticosterone. The unique responses of adolescents to nicotine are consistent with an immature function of nicotinic acetylcholine receptors at this age.
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影响因子：
--
作者：
CRITCHLOW, V;BARSELA, M;LIPSCOMB, HS
通讯作者：
LIPSCOMB, HS
影响因子：
7.6
作者：
Adriani, W;Macrì, S;Laviola, G
通讯作者：
Laviola, G
影响因子：
7.6
作者：
Cao, Junran;Lotfipour, Shahrdad;Leslie, Frances M.
通讯作者：
Leslie, Frances M.
影响因子：
3.7
作者：
Caggiula, AR;Donny, EC;Perkins, KA
通讯作者：
Perkins, KA
影响因子：
3.6
作者：
BALFOUR, DJK;KHULLAR, AK;LONGDEN, A
通讯作者：
LONGDEN, A