Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4.
Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4.
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长非编码RNA胃癌相关lncRNA1通过miRNA-885-3p和细胞周期蛋白依赖性激酶4介导胃恶性肿瘤
DOI：
10.1038/s41419-018-0643-5
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发表时间：
2018-05-22
影响因子：
9
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Lin Z;Zhou Z;Guo H;He Y;Pang X;Zhang X;Liu Y;Ao X;Li P;Wang J
胃癌是我国最常见的恶性肿瘤之一，居恶性肿瘤死亡的第三位。长链非编码RNA（longnoncodingRNA，lncRNA）与包括胃癌在内的多种肿瘤有密切关系，但许多功能性lncRNA的作用机制尚不清楚。在这项研究中，我们鉴定了在GC细胞和患者肿瘤组织中大量表达的lncRNA，RP 11 -290F20.3。我们将这种lncRNA命名为GC相关lncRNA 1（GCRL 1），它在体内外均能调节胃细胞的增殖和转移。miRNA-885- 3 p（miR-885- 3 p）通过在转录后水平下调细胞周期蛋白依赖性激酶4（cyclin-dependent kinase 4，CDK 4）的表达，抑制胃癌细胞的增殖和转移。此外，GCRL 1通过海绵状吸收miR-885- 3 p促进细胞增殖和转移，从而在GC细胞中正调节CDK 4。综上所述，我们的研究结果表明，胃癌中恶性细胞增殖和侵袭的新调控轴，包括GCRL 1，miR-885- 3 p和CDK 4，可能作为胃癌的潜在治疗靶点。
Gastric cancer (GC) is one of the most common malignancy and the third leading cancer-related death in China. Long noncoding RNAs (lncRNAs) have been implicated in numerous tumors, including GC, however, the mechanism of many functional lncRNAs is still unclear. In this study, we identified the abundantly expressed lncRNA, RP11-290F20.3, in GC cells and patient tumor tissues. We named this lncRNA as GC-related lncRNA1 (GCRL1), which could regulate gastric cell proliferation and metastasis, both in vitro and in vivo. Mechanistically, miRNA-885-3p (miR-885-3p) could inhibit the cell proliferation and metastasis in GC by negatively regulating the expression of cyclin-dependent kinase 4 (CDK4) at the post-transcriptional level. Further, GCRL1 promoted the cell proliferation and metastasis by sponging miR-885-3p and hence, positively regulating CDK4 in GC cells. Taken together, our results demonstrate a novel regulatory axis of malignant cell proliferation and invasion in GC, comprising GCRL1, miR-885-3p, and CDK4, which may serve as a potential therapeutic target in GC.
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影响因子：
24.5
作者：
Han TS;Hur K;Xu G;Choi B;Okugawa Y;Toiyama Y;Oshima H;Oshima M;Lee HJ;Kim VN;Chang AN;Goel A;Yang HK
通讯作者：
Yang HK
影响因子：
50.3
作者：
Hu X;Feng Y;Zhang D;Zhao SD;Hu Z;Greshock J;Zhang Y;Yang L;Zhong X;Wang LP;Jean S;Li C;Huang Q;Katsaros D;Montone KT;Tanyi JL;Lu Y;Boyd J;Nathanson KL;Li H;Mills GB;Zhang L
通讯作者：
Zhang L
MicroRNA-141通过靶向促膜胃基因来抑制前列腺癌干细胞和转移。
影响因子：
16.6
作者：
Liu C;Liu R;Zhang D;Deng Q;Liu B;Chao HP;Rycaj K;Takata Y;Lin K;Lu Y;Zhong Y;Krolewski J;Shen J;Tang DG
通讯作者：
Tang DG
影响因子：
64.5
作者：
Atianand MK;Hu W;Satpathy AT;Shen Y;Ricci EP;Alvarez-Dominguez JR;Bhatta A;Schattgen SA;McGowan JD;Blin J;Braun JE;Gandhi P;Moore MJ;Chang HY;Lodish HF;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
8.8
作者：
Nygren, M. K.;Tekle, C.;Ingebrigtsen, V. A.;Makela, R.;Krohn, M.;Aure, M. R.;Nunes-Xavier, C. E.;Perala, M.;Tramm, T.;Alsner, J.;Overgaard, J.;Nesland, J. M.;Borgen, E.;Borresen-Dale, A-L;Fodstad, O.;Sahlberg, K. K.;Leivonen, S-K
通讯作者：
Leivonen, S-K