Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease.
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease.
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DOI：
10.1111/jnc.12675
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发表时间：
2014-06
影响因子：
4.7
通讯作者：
Small DH
中科院分区：
文献类型：
--
作者：
Dawkins E;Small DH
β-淀粉样前体蛋白（APP）作为阿尔茨海默病的β-淀粉样蛋白（Aβ）的前体蛋白，已被广泛研究。然而，APP的正常功能在很大程度上仍然未知。本文综述了APP的结构、表达、翻译后加工以及APP在体内外的作用。我们的结论是，公布的数据提供了强有力的证据，APP具有营养功能。APP可能参与神经干细胞发育、神经元存活、轴突生长和神经修复。然而，APP发挥其作用的机制仍有待阐明。现有的证据表明，APP在细胞内和细胞外相互作用，以调节各种信号转导机制。本文综述了淀粉样前体蛋白（APP）的结构、表达、翻译后加工以及APP在体内外的作用。我们的结论是，公布的数据提供了强有力的证据，APP具有营养功能。APP可能参与神经干细胞发育、神经元存活、轴突生长和神经修复。然而，APP发挥其作用的机制仍有待阐明。现有的证据表明，APP在细胞内和细胞外相互作用，以调节各种信号转导机制。
The β-amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the β-amyloid protein (Aβ) of Alzheimer's disease. However, the normal function of APP remains largely unknown. This article reviews studies on the structure, expression and post-translational processing of APP, as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms. This article reviews studies on the structure, expression and post-translational processing of β-amyloid precursor protein (APP), as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms.
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影响因子：
4.8
作者：
Buxbaum, JD;Liu, KN;Black, RA
通讯作者：
Black, RA
DOI：
10.1016/s0006-291x(05)81412-3
发表时间：
1991-11-27
影响因子：
3.1
作者：
ARAKI, W;KITAGUCHI, N;KIMURA, J
通讯作者：
KIMURA, J
DOI：
10.1016/s0169-328x(98)00037-0
发表时间：
1998-05-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Akar, CA;Wallace, WC
通讯作者：
Wallace, WC
影响因子：
56.9
作者：
Cao, XW;Südhof, TC
通讯作者：
Südhof, TC
影响因子：
5.3
作者：
Bozkulak, Esra Cagavi;Weinmaster, Gerry
通讯作者：
Weinmaster, Gerry