Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
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DOI：
10.1084/jem.20082818
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发表时间：
2009-08-31
期刊：
影响因子：
--
通讯作者：
Reis e Sousa C
中科院分区：
文献类型：
--
作者：
Robinson MJ;Osorio F;Rosas M;Freitas RP;Schweighoffer E;Gross O;Verbeek JS;Ruland J;Tybulewicz V;Brown GD;Moita LF;Taylor PR;Reis e Sousa C
先天免疫细胞通过模式识别受体（PRR）检测病原体，PRR发出启动对感染的免疫反应的信号。Dectin-1是一种真菌的PRR，其研究已经确定了一种涉及Syk激酶和衔接子CARD 9的新型先天信号传导途径，该途径对于诱导Th 17对真菌感染的应答至关重要。我们发现，另一种C型凝集素，Dectin-2，也通过Syk和CARD 9信号，并有助于树突状细胞（DC）激活真菌颗粒。与Dectin-1不同，Dectin-2通过与FcRγ链结合间接偶联至Syk。在白色念珠菌感染的模型中，Dectin-2的阻断不影响先天性免疫抵抗，但废除了白念珠菌特异性T细胞产生IL-17，并与Dectin-1的缺乏相结合，降低了Th 1对生物体的反应。因此，Dectin-2构成主要的真菌PRR，其可以偶联至Syk-CARD 9先天信号传导途径以激活DC并调节针对真菌感染的适应性免疫应答。
Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducing Th17 responses to fungal infection. We show that another C-type lectin, Dectin-2, also signals via Syk and CARD9, and contributes to dendritic cell (DC) activation by fungal particles. Unlike Dectin-1, Dectin-2 couples to Syk indirectly, through association with the FcRγ chain. In a model of Candida albicans infection, blockade of Dectin-2 did not affect innate immune resistance but abrogated Candida-specific T cell production of IL-17 and, in combination with the absence of Dectin-1, decreased Th1 responses to the organism. Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.
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影响因子：
4.3
作者：
Carter, Robert W.;Thompson, Clare;Tough, David F.
通讯作者：
Tough, David F.
DOI：
10.4049/jimmunol.182.2.1119
发表时间：
2009-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Barrett NA;Maekawa A;Rahman OM;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y
影响因子：
64.8
作者：
Gross, Olaf;Gewies, Andreas;Ruland, Juergen
通讯作者：
Ruland, Juergen
影响因子：
4.8
作者：
Cambi, Alessandra;Netea, Mihai G.;Figdor, Carl G.
通讯作者：
Figdor, Carl G.
影响因子：
6.4
作者：
Huang, WT;Na, L;Schwarzenberger, P
通讯作者：
Schwarzenberger, P