Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
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DOI：
10.1016/j.cytogfr.2010.09.001
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发表时间：
2010-10
影响因子：
13
通讯作者：
Walter, Mark R.
中科院分区：
文献类型：
--
作者：
Donnelly, Raymond P.;Sheikh, Faruk;Dickensheets, Harold;Savan, Ram;Young, Howard A.;Walter, Mark R.
IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells. It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains. IL-26 receptors are primarily expressed on non-hematopoietic cell types, particularly epithelial cells. Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined.
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