Changes in brain activation in stroke patients after mental practice and physical exercise: a functional MRI study.
Changes in brain activation in stroke patients after mental practice and physical exercise: a functional MRI study.
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DOI：
10.4103/1673-5374.139465
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发表时间：
2014-08-01
影响因子：
6.1
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Liu H;Song L;Zhang T
心理练习是一种新的康复方法，是指以提高运动成绩为目标的运动表象内容的心理排练。然而，激活的区域和运动恢复后的心理练习训练的关系还没有得到很好的理解。在这项研究中，招募了15名首次发生皮质下卒中的患者，这些患者伴有影响右手的神经功能缺损，但没有明显的认知障碍。10例患者采用心理训练结合体能训练，5例患者仅采用体能训练。观察4周训练后大脑激活区的变化，探讨激活变化与患手功能恢复的相关性。结果表明，经过4周的心理训练与体能训练相结合后，患侧右手的Fugl-Meyer评定评分较单独训练4周后显著提高。功能性磁共振成像显示增强激活左侧初级躯体感觉皮层，衰减激活强度在右侧初级运动皮层，并增强在运动想象任务中观察到的右侧小脑激活，使用受影响的右手心理练习训练后。脑皮质活动的变化与手功能的恢复有关。实验结果表明，大脑皮层和小脑的功能重组后的心理练习有助于手功能的改善。
Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered a first-ever subcortical stroke with neurological deficits affecting the right hand, but no significant cognitive impairment were recruited. 10 patients underwent mental practice combined with physical practice training, and 5 patients only underwent physical practice training. We observed brain activation regions after 4 weeks of training, and explored the correlation of activation changes with functional recovery of the affected hands. The results showed that, after 4 weeks of mental practice combined with physical training, the Fugl-Meyer assessment score for the affected right hand was significantly increased than that after 4 weeks of practice training alone. Functional MRI showed enhanced activation in the left primary somatosensory cortex, attenuated activation intensity in the right primary motor cortex, and enhanced right cerebellar activation observed during the motor imagery task using the affected right hand after mental practice training. The changes in brain cortical activity were related to functional recovery of the hand. Experimental findings indicate that cortical and cerebellar functional reorganization following mental practice contributed to the improvement of hand function.
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影响因子：
5.7
作者：
Grefkes C;Nowak DA;Wang LE;Dafotakis M;Eickhoff SB;Fink GR
通讯作者：
Fink GR
影响因子：
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作者：
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