Recordings from the facial nucleus in the rat: signs of abnormal facial muscle response.
Recordings from the facial nucleus in the rat: signs of abnormal facial muscle response.
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大鼠面部核的记录：面部肌肉反应异常的迹象。
DOI：
10.1007/bf00230096
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发表时间：
1990
影响因子：
2
通讯作者：
Sen,CN
中科院分区：
文献类型：
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作者：
Møller,AR;Sen,CN
根据微血管减压术(MVD)解除面肌痉挛(HFS)患者的电生理研究结果，我们推测HFS患者特有的肌肉反应异常是血管刺激面神经的结果，血管压迫面神经出口附近的脑干。当面神经的一个分支受到电刺激时，这种异常的肌肉反应就会出现，并通过由面神经的其他分支支配的肌肉进行记录。我们进一步假设，HFS患者的面神经核过度活跃，痉挛和肌肉反应异常是一种被称为“点燃”的现象的结果。这些假说得到了最近的研究的支持，这些研究表明，对脑干附近的大鼠面神经干进行慢性电刺激会导致类似于HFS患者的异常肌肉反应。本文报道了反复电刺激面神经的大鼠面神经运动核团的记录结果。结果表明，这些大鼠的肌肉反应异常是由面神经运动核功能的改变引起的。我们将这些结果解释为表明，引起人类HFS症状的生理异常位于面神经运动核，而核功能的变化是由血管与面神经密切接触引起的慢性逆行神经活动引起的。
On the basis of results of electrophysiological studies in patients undergoing microvascular decompression (MVD) operations to relieve hemifacial spasm (HFS), we have postulated that the abnormal muscle response characteristically found in patients with HFS is the result of irritation of the facial nerve by the blood vessel that is compressing the facial nerve near its exit from the brainstem in these patients. This abnormal muscle response is seen when one branch of the facial nerve is electrically stimulated and recordings are made from muscles that are innervated by other branches of the facial nerve. We further hypothesized that the facial nucleus is hyperactive in patients with HFS and that the spasm and the abnormal muscle response are results of a phenomenon known as “kindling”. These hypotheses are supported by recent studies showing that chronic electrical stimulation of the facial nerve trunk in rats near the brainstem results in an abnormal muscle response that is similar to that seen in patients with HFS. In this paper, we present the results of recording from the facial motonucleus in rats that had been subjected to repeated electrical stimulation of the facial nerve. The results indicate that the abnormal muscle response in these rats was caused by changes in the function of the facial motonucleus. We interpret these results as showing that the physiological abnormalities that give rise to the signs of HFS in man are located in the facial motonucleus, and that the changes in the function of the nucleus are produced by chronic antidromic neural activity resulting from close contact between a blood vessel and the facial nerve.
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影响因子：
20.1
作者：
T. Oshima;M. Currie;D. Geller;P. Needleman
通讯作者：
P. Needleman
影响因子：
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作者：
ACKERMANN, U;IRIZAWA, TG;SONNENBERG, H
通讯作者：
SONNENBERG, H
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影响因子：
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作者：
R. Winquist;E. Faison;R. Nutt
通讯作者：
R. Nutt
加压素抑制交感神经节传递，但增强兔子后肢脉管系统的交感神经效应器反应。
DOI：
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发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Patel,KP;Schmid,PG
通讯作者：
Schmid,PG
混凝土工程年会论文集7。（1985）
DOI：
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发表时间：
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期刊：
影响因子：
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作者：
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