Risk factors of peptic ulcer disease: Different impact of Helicobacter pylori in Dutch and Japanese populations?
Risk factors of peptic ulcer disease: Different impact of Helicobacter pylori in Dutch and Japanese populations?
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消化性溃疡病的危险因素：幽门螺杆菌对荷兰和日本人群的不同影响？
DOI：
10.1111/j.1440-1746.1996.tb00087.x
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发表时间：
1996
影响因子：
4.1
通讯作者：
C. Lamers
中科院分区：
文献类型：
--
作者：
R. Schlemper;SJOERD DJ Werf;J. Vandenbroucke;I. Biemond;C. Lamers
据报道，幽门螺杆菌、非甾体抗炎药、家族史、O型血型、高胃蛋白酶原血症A、酒精和吸烟是消化性溃疡的风险因素。因果风险因素的强度在不同人群中可能不同。在年龄、性别和职业类型相似的215名日本雇员和493名荷兰雇员中，使用问卷调查获得结构化病史，并分析空腹血清样本中的H.幽门螺杆菌和胃蛋白酶原A都在同一个实验室通过病例记录验证了既往溃疡史。我们发现H.幽门螺杆菌血清阳性、高血清胃蛋白酶原A和溃疡病家族史是消化性溃疡病的重要和独立的危险因素。螺杆幽门螺杆菌血清阳性，荷兰人的风险增加了20倍，日本人的风险增加了8倍。H.在20例有经证实的溃疡病史的荷兰受试者中，幽门螺杆菌感染率为90%，在41例日本溃疡受试者中，幽门螺杆菌感染率为95%;在荷兰非溃疡受试者中，幽门螺杆菌感染率为29%，在日本非溃疡受试者中为70%。在48岁时，H。幽门感染和未感染受试者的日本受试者比例为24.5-3.0 = 21.5%，荷兰受试者比例为11.8-0.5 = 11.3%。十二指肠溃疡病与高咖啡消费仅在日本人群中相关，在那里这种习惯远不如荷兰人流行。总之，将消化性溃疡危险因素定性为弱或强没有普遍的基础：目前的研究表明，从诊断的角度来看，H。在血清阳性率较高的社会中，幽门螺杆菌似乎是消化性溃疡病的一个较弱的危险因素。然而，从病原学的角度来看，H。幽门螺杆菌对日本人溃疡发病率的影响甚至大于荷兰人。
Helicobacter pylori, non‐steroidal anti‐inflammatory drugs, family history, blood group O, hyperpepsinogenaemia A, alcohol and smoking have been reported to be risk factors for peptic ulcer disease. The strength of causal risk factors may differ in different populations. In 215 Japanese and 493 Dutch employees of similar age, gender and type of occupation, a structured history was obtained using a questionnaire and fasting serum samples were analysed for IgG antibodies to H. pylori and pepsinogen A all in the same laboratory. A past ulcer history was verified through case notes. We found that H. pylori seropositivity, a high serum pepsinogen A and a family history of ulcer disease were significant and independent risk factors for peptic ulcer disease. For H. pylori seropositivity there was a 20‐fold increased risk among the Dutch and an eight‐fold increased risk among the Japanese. The seroprevalence of H. pylori was 90% in 20 Dutch subjects with a verified ulcer history and 95% in 41 Japanese ulcer subjects; it was 29% in Dutch non‐ulcer subjects and 70% in Japanese non‐ulcer subjects. The cumulative difference in risk to develop peptic ulcer disease at the age of 48 years between H. pylor‐infected and ‐uninfected subjects was 24.5–3.0 = 21.5% for the Japanese and 11.8–0.5 = 11.3% for the Dutch. Duodenal ulcer disease was associated with a high coffee consumption only among the Japanese population, where this habit was much less prevalent than among the Dutch. In conclusion, the characterization of peptic ulcer risk factors as weak or strong has no universal basis: the present study shows that from a diagnostic point of view H. pylori appears to be a weaker risk factor for peptic ulcer disease in a society with a higher seroprevalence. However, from an aetiological point of view, H. pylori has an even greater impact on ulcer morbidity in the Japanese than in the Dutch population.
影响因子：
29.4
作者：
M. N. Peters;C. T. Richardson
通讯作者：
M. N. Peters;C. T. Richardson
患有消化性溃疡病的男性的生活事件压力和心理社会因素。
影响因子：
29.4
作者：
Walker,P;Luther,J;Samloff,IM;Feldman,M
通讯作者：
Feldman,M