Ubiquitin-like proteins and their roles in archaea.

Ubiquitin-like proteins and their roles in archaea.
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DOI:
10.1016/j.tim.2012.09.006
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发表时间:
2013-01
影响因子:
15.9
通讯作者:
Maupin-Furlow, Julie A.
Maupin-Furlow, Julie A.
中科院分区:
生物学1区
文献类型:
--
作者:
Maupin-Furlow, Julie A.

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This review highlights the finding that ubiquitin-like (Ubl) proteins of archaea (termed SAMPs) function not only as sulfur carriers but also as protein modifiers. UbaA (an E1 ubiquitin-activating enzyme homolog of archaea) is required for the SAMPs to be covalently attached to proteins. The SAMPs and UbaA are also needed to form sulfur-containing biomolecules (e.g., thiolated tRNA and molybdenum cofactor). These findings provide a new perspective on how Ubl-proteins can serve as both sulfur carriers and protein modifiers in the absence of canonical E2 ubiquitin conjugating or E3 ubiquitin ligase enzyme homologs.
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