Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry.
Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry.
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DOI：
10.1167/tvst.11.5.15
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发表时间：
2022-05-02
影响因子：
3
通讯作者：
MacLaren, Robert E.
中科院分区：
文献类型：
--
作者：
Buckley, Thomas M. W.;Josan, Amandeep Singh;Taylor, Laura J.;Jolly, Jasleen K.;Cehajic-Kapetanovic, Jasmina;MacLaren, Robert E.
在RPGR相关的视网膜色素变性中，静态自动视野检查法和动态视野检查法对周边视野的定义不一样。本研究探讨了周边视野的模式和敏感性，这可能是评估介入性临床试验时的重要终点。对10例经遗传学证实的RPGR受试者进行了回顾性观察性横断面研究。使用Octopus 900视野计获得视野。对两眼间对称性和重复性进行定量。视野被细分为中央和周边子字段进行分析。患者平均年龄为32岁（20 - 49岁）。右眼和左眼的平均灵敏度分别为7 dB（SD = 3.67 dB）和6.8 dB（SD = 3.4 dB），表明两眼间对称。总体平均灵敏度的重复性系数：<2 dB。10名受试者中有9名有保留的颞下亚区，其平均灵敏度与中心场高度相关（右眼和左眼分别为r2 = 0.78，P = 0.002和r2 = 0.72，P = 0.002）。在中央视野内，颞侧的灵敏度高于鼻侧（t检验，右眼和左眼分别为P = 0.01和P = 0.03）。Octopus静态自动视野计具有良好的重复性。眼间对称性允许使用非介入眼作为内部对照。在这个队列中，颞下和中央视野被保留到后期疾病阶段，可能映射到存活的视锥细胞群体。一个持续保存的颞下视觉岛高度相关的中央视野可能有意义的未来可能的治疗网站。
Peripheral visual fields have not been as well defined by static automated perimetry as kinetic perimetry in RPGR-related retinitis pigmentosa. This study explores the pattern and sensitivities of peripheral visual fields, which may provide an important end point when assessing interventional clinical trials. A retrospective observational cross-sectional study of 10 genetically confirmed RPGR subjects was performed. Visual fields were obtained using the Octopus 900 perimeter. Interocular symmetry and repeatability were quantified. Visual fields were subdivided into central and peripheral subfields for analysis. Mean patient age was 32 years old (20 to 49 years old). Average mean sensitivity was 7 dB (SD = 3.67 dB) and 6.8 dB (SD = 3.4 dB) for the right and left eyes, respectively, demonstrating interocular symmetry. Coefficient of repeatability for overall mean sensitivity: <2 dB. Nine out of 10 subjects had a preserved inferotemporal subfield, whose mean sensitivity was highly correlated to the central field (r2 = 0.78, P = 0.002 and r2 = 0.72, P = 0.002 for the right and left eyes, respectively). Within the central field, sensitivities were greater in the temporal than the nasal half (t-test, P = 0.01 and P = 0.03 for the right and left eyes, respectively). Octopus static-automated perimeter demonstrates good repeatability. Interocular symmetry permits use of the noninterventional eye as an internal control. In this cohort, the inferotemporal and central visual fields are preserved into later disease stages likely mapping to populations of surviving cones. A consistently preserved inferotemporal island of vision highly correlated to that of the central visual field may have significance as a possible future therapeutic site.
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影响因子：
4.4
作者：
Kumaran N;Rubin GS;Kalitzeos A;Fujinami K;Bainbridge JWB;Weleber RG;Michaelides M
通讯作者：
Michaelides M
影响因子：
4.4
作者：
Cideciyan, Artur V.;Charng, Jason;Jacobson, Samuel G.
通讯作者：
Jacobson, Samuel G.
影响因子：
1.4
作者：
Geruschat, DR;Turano, KA;Stahl, JW
通讯作者：
Stahl, JW
影响因子：
4.4
作者：
Kim, Linda S.;McAnany, J. Jason;Fishman, Gerald A.
通讯作者：
Fishman, Gerald A.
影响因子：
2
作者：
Hirasawa, Kazunori;Shoji, Nobuyuki
通讯作者：
Shoji, Nobuyuki